{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["PhD Research Fund of the Affiliated Hospital of the Southwest Medical University","Luzhou city: Southwest Medical University Joint Project","Scientific Research Fund of Southwest Medical University"],"pagination":["117"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6794830"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Human Papilloma Virus (HPV) DNA tests are highly sensitive and can triage women with mild lesions, improving the prognosis and diagnosis of cervical lesions. However, additional efficient strategies should be developed to improve the specificity of these tests.<h4>Methods</h4>This study aimed to evaluate the clinical value of HPV DNA load in improving the diagnosis and prognosis of cervical lesions by p16/Ki-67 testing. Histological samples were collected from 350 women with HR-HPV genotyping and analyzed by qRT-PCR. Immunohistochemical staining was used to assess p16 and Ki-67 expression and clinical performance characteristics were calculated.<h4>Results</h4>Of the cases, 271 had detectable HR-HPV infection, in which HPV-16 was most prevalent (52.0%), followed by HPV-5"],"journal":["Virology journal"],"pubmed_title":["Combining HPV DNA load with p16/Ki-67 staining to detect cervical precancerous lesions and predict the progression of CIN1-2 lesions."],"pmcid":["PMC6794830"],"funding_grant_id":["16238","2017LZXNYD-PO2","0930-00031081"],"pubmed_authors":["Li Y","Liu J","Long W","Gong L","Sun X"],"additional_accession":[]},"is_claimable":false,"name":"Combining HPV DNA load with p16/Ki-67 staining to detect cervical precancerous lesions and predict the progression of CIN1-2 lesions.","description":"<h4>Background</h4>Human Papilloma Virus (HPV) DNA tests are highly sensitive and can triage women with mild lesions, improving the prognosis and diagnosis of cervical lesions. However, additional efficient strategies should be developed to improve the specificity of these tests.<h4>Methods</h4>This study aimed to evaluate the clinical value of HPV DNA load in improving the diagnosis and prognosis of cervical lesions by p16/Ki-67 testing. Histological samples were collected from 350 women with HR-HPV genotyping and analyzed by qRT-PCR. Immunohistochemical staining was used to assess p16 and Ki-67 expression and clinical performance characteristics were calculated.<h4>Results</h4>Of the cases, 271 had detectable HR-HPV infection, in which HPV-16 was most prevalent (52.0%), followed by HPV-5","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2025-04-26T16:40:19.533Z","creation":"2019-11-05T08:06:25Z"},"accession":"S-EPMC6794830","cross_references":{"pubmed":["31619262"],"doi":["10.1186/s12985-019-1225-6"]}}