{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Nielsen MJ"],"pubmed_abstract":["Following liver transplantation (LT), 10-30% of patients develop recurrent cirrhosis (RC). There is an urgent need for predictive non-invasive markers for improved monitoring of these patients. Here we studied extracellular matrix biomarkers as predictors of RC after LT. Forty-seven LT patients were divided into groups of fast, intermediate or non-progressors towards RC (<1 year, 3-5 years or no advanced fibrosis >5 years after LT), assessed by follow-up liver biopsies. Markers of interstitial matrix type III and V collagen formation (PRO-C3 and PRO-C5), basement membrane type IV collagen formation (PRO-C4) and degradation (C4M) were assessed in serum samples collected 3, 6 and 12 months post-LT using specific ELISAs. PRO-C3, PRO-C4, and C4M were elevated in fast progressors compared to no"],"journal":["Scientific reports"],"pagination":["14857"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6796007"],"repository":["biostudies-literature"],"pubmed_title":["Serum markers of type III and IV procollagen processing predict recurrence of fibrosis in liver transplanted patients."],"pmcid":["PMC6796007"],"pubmed_authors":["Leeming DJ","Krag A","Gudmann NS","Zimmermann T","Villesen IF","Nielsen MJ","Karsdal MA","Schuppan D"],"additional_accession":[]},"is_claimable":false,"name":"Serum markers of type III and IV procollagen processing predict recurrence of fibrosis in liver transplanted patients.","description":"Following liver transplantation (LT), 10-30% of patients develop recurrent cirrhosis (RC). There is an urgent need for predictive non-invasive markers for improved monitoring of these patients. Here we studied extracellular matrix biomarkers as predictors of RC after LT. Forty-seven LT patients were divided into groups of fast, intermediate or non-progressors towards RC (<1 year, 3-5 years or no advanced fibrosis >5 years after LT), assessed by follow-up liver biopsies. Markers of interstitial matrix type III and V collagen formation (PRO-C3 and PRO-C5), basement membrane type IV collagen formation (PRO-C4) and degradation (C4M) were assessed in serum samples collected 3, 6 and 12 months post-LT using specific ELISAs. PRO-C3, PRO-C4, and C4M were elevated in fast progressors compared to no","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2026-05-07T05:54:19.918Z","creation":"2026-04-07T22:39:57.912Z"},"accession":"S-EPMC6796007","cross_references":{"pubmed":["31619707"],"doi":["10.1038/s41598-019-51394-4"]}}