biostudies-literatureUnknown9(1)Nielsen MJFollowing liver transplantation (LT), 10-30% of patients develop recurrent cirrhosis (RC). There is an urgent need for predictive non-invasive markers for improved monitoring of these patients. Here we studied extracellular matrix biomarkers as predictors of RC after LT. Forty-seven LT patients were divided into groups of fast, intermediate or non-progressors towards RC (<1 year, 3-5 years or no advanced fibrosis >5 years after LT), assessed by follow-up liver biopsies. Markers of interstitial matrix type III and V collagen formation (PRO-C3 and PRO-C5), basement membrane type IV collagen formation (PRO-C4) and degradation (C4M) were assessed in serum samples collected 3, 6 and 12 months post-LT using specific ELISAs. PRO-C3, PRO-C4, and C4M were elevated in fast progressors compared to noScientific reports14857https://www.ebi.ac.uk/biostudies/studies/S-EPMC6796007biostudies-literatureSerum markers of type III and IV procollagen processing predict recurrence of fibrosis in liver transplanted patients.PMC6796007Leeming DJKrag AGudmann NSZimmermann TVillesen IFNielsen MJKarsdal MASchuppan DfalseSerum markers of type III and IV procollagen processing predict recurrence of fibrosis in liver transplanted patients.Following liver transplantation (LT), 10-30% of patients develop recurrent cirrhosis (RC). There is an urgent need for predictive non-invasive markers for improved monitoring of these patients. Here we studied extracellular matrix biomarkers as predictors of RC after LT. Forty-seven LT patients were divided into groups of fast, intermediate or non-progressors towards RC (<1 year, 3-5 years or no advanced fibrosis >5 years after LT), assessed by follow-up liver biopsies. Markers of interstitial matrix type III and V collagen formation (PRO-C3 and PRO-C5), basement membrane type IV collagen formation (PRO-C4) and degradation (C4M) were assessed in serum samples collected 3, 6 and 12 months post-LT using specific ELISAs. PRO-C3, PRO-C4, and C4M were elevated in fast progressors compared to no2019-01-01T00:00:00Z2019 Oct2026-05-07T05:54:19.918Z2026-04-07T22:39:57.912ZS-EPMC67960073161970710.1038/s41598-019-51394-4