biostudies-literatureUnknown20(1)Li J<h4>Background</h4>The study aims at scientifically investigating the genetic effect of four polymorphisms (rs7975232, rs1544410, rs2228570, and rs731236) within the human Vitamin D Receptor (VDR) gene on the odds of psoriasis through an updated meta-analysis.<h4>Methods</h4>We searched eight databases and screened the studies for pooling. Finally, a total of eighteen eligible case-control studies were included. BH (Benjamini & Hochberg) adjusted P-values of association (P_association) and odd ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated under the allele, homozygote, heterozygote, dominant, recessive, and carrier models.<h4>Results</h4>Compared with the negative controls, no statistically significant difference in the odds of psoriasis was deBMC medical genetics161https://www.ebi.ac.uk/biostudies/studies/S-EPMC6796361biostudies-literaturePooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis.PMC6796361Sun LYan MLi JSun JfalsePooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis.<h4>Background</h4>The study aims at scientifically investigating the genetic effect of four polymorphisms (rs7975232, rs1544410, rs2228570, and rs731236) within the human Vitamin D Receptor (VDR) gene on the odds of psoriasis through an updated meta-analysis.<h4>Methods</h4>We searched eight databases and screened the studies for pooling. Finally, a total of eighteen eligible case-control studies were included. BH (Benjamini & Hochberg) adjusted P-values of association (P_association) and odd ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated under the allele, homozygote, heterozygote, dominant, recessive, and carrier models.<h4>Results</h4>Compared with the negative controls, no statistically significant difference in the odds of psoriasis was de2019-01-01T00:00:00Z2019 Oct2026-05-03T16:34:42.661Z2019-11-05T08:06:58ZS-EPMC67963613162356810.1186/s12881-019-0896-6