{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Paulikova G"],"pubmed_abstract":["A recently described bangle lectin (PHL) from the bacterium Photorhabdus asymbiotica was identified as a mainly fucose-binding protein that could play an important role in the host-pathogen interaction and in the modulation of host immune response. Structural studies showed that PHL is a homo-dimer that contains up to seven L-fucose-specific binding sites per monomer. For these reasons, potential ligands of the PHL lectin: α-L-fucopyranosyl-containing mono-, di-, tetra-, hexa- and dodecavalent ligands were tested. Two types of polyvalent structures were investigated - calix[4]arenes and dendrimers. The shared feature of all these structures was a C-glycosidic bond instead of the more common but physiologically unstable O-glycosidic bond. The inhibition potential of the tested structures wa"],"journal":["Scientific reports"],"pagination":["14904"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6797808"],"repository":["biostudies-literature"],"pubmed_title":["Fucosylated inhibitors of recently identified bangle lectin from Photorhabdus asymbiotica."],"pmcid":["PMC6797808"],"pubmed_authors":["Wimmerova M","Parkan K","Moravcova J","Bertolotti B","Oroszova B","Paulikova G","Houser J","Kasakova M"],"additional_accession":[]},"is_claimable":false,"name":"Fucosylated inhibitors of recently identified bangle lectin from Photorhabdus asymbiotica.","description":"A recently described bangle lectin (PHL) from the bacterium Photorhabdus asymbiotica was identified as a mainly fucose-binding protein that could play an important role in the host-pathogen interaction and in the modulation of host immune response. Structural studies showed that PHL is a homo-dimer that contains up to seven L-fucose-specific binding sites per monomer. For these reasons, potential ligands of the PHL lectin: α-L-fucopyranosyl-containing mono-, di-, tetra-, hexa- and dodecavalent ligands were tested. Two types of polyvalent structures were investigated - calix[4]arenes and dendrimers. The shared feature of all these structures was a C-glycosidic bond instead of the more common but physiologically unstable O-glycosidic bond. The inhibition potential of the tested structures wa","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2025-04-22T00:40:49.281Z","creation":"2019-11-05T08:11:54Z"},"accession":"S-EPMC6797808","cross_references":{"pubmed":["31624296"],"doi":["10.1038/s41598-019-51357-9"]}}