biostudies-literatureUnknown8(11)Gallegos ACObjective: There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic wound, compared with levels in patients after timolol ocular administration for the indication of glaucoma. Results: There was no statistically significant difference in the average plasma level of timolol in wound as compared with glaucoma patients. No bradycardia or wheezing was observed after administration. Innovation: We determined the single time point concentration of timolol in plasma 1 h after application of timolol 0.5% gel-forming solution to debrided chronic woundsAdvances in wound care538-545https://www.ebi.ac.uk/biostudies/studies/S-EPMC6798797biostudies-literatureAbsorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds.PMC6798797West KPeavy TRDixon RWIsseroff RRTchanque-Fossuo CNPatel RPGallegos ACDahle SEDavis MJEisentrout-Melton AfalseAbsorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds.Objective: There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic wound, compared with levels in patients after timolol ocular administration for the indication of glaucoma. Results: There was no statistically significant difference in the average plasma level of timolol in wound as compared with glaucoma patients. No bradycardia or wheezing was observed after administration. Innovation: We determined the single time point concentration of timolol in plasma 1 h after application of timolol 0.5% gel-forming solution to debrided chronic wounds2019-01-01T00:00:00Z2019 Nov2025-04-26T16:49:39.569Z2019-11-05T08:08:00ZS-EPMC67987973163710010.1089/wound.2019.0970