{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bojang A"],"funding":["DFID","Department of Microbiology &amp; Immunology","Doherty Applied Microbial Genomics","UK MRC","MRC/DFID","University of Melbourne at The Peter Doherty Institute for Infection &amp; Immunity","T. P. S.","EDCTP2 programme","B. P. H.","National Health and Medical Research Council of Australia","European Union","UK Department for International Development","Medical Research Council"],"pagination":["3170-3178"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6798832"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(11)"],"pubmed_abstract":["<h4>Background</h4>Oral azithromycin given during labour reduces carriage of bacteria responsible for neonatal sepsis, including Staphylococcus aureus. However, there is concern that this may promote drug resistance.<h4>Objectives</h4>Here, we combine genomic and epidemiological data on S. aureus isolated from mothers and babies in a randomized intra-partum azithromycin trial (PregnAnZI) to describe bacterial population dynamics and resistance mechanisms.<h4>Methods</h4>Participants from both arms of the trial, who carried S. aureus in day 3 and day 28 samples post-intervention, were included. Sixty-six S. aureus isolates (from 7 mothers and 10 babies) underwent comparative genome analyses and the data were then combined with epidemiological data. Trial registration (main trial): ClinicalT"],"journal":["The Journal of antimicrobial chemotherapy"],"pubmed_title":["Genomic investigation of Staphylococcus aureus recovered from Gambian women and newborns following an oral dose of intra-partum azithromycin."],"pmcid":["PMC6798832"],"funding_grant_id":["MR/R010161/1","GNT1008549","GNT1105905"],"pubmed_authors":["Goncalves da Silva A","Roca A","Guerillot R","Stevens K","Donovan L","Bojang A","Stinear TP","Secka O","Bottomley C","Baines SL","Higgs C","Howden BP","Seemann T","Schultz MB"],"additional_accession":[]},"is_claimable":false,"name":"Genomic investigation of Staphylococcus aureus recovered from Gambian women and newborns following an oral dose of intra-partum azithromycin.","description":"<h4>Background</h4>Oral azithromycin given during labour reduces carriage of bacteria responsible for neonatal sepsis, including Staphylococcus aureus. However, there is concern that this may promote drug resistance.<h4>Objectives</h4>Here, we combine genomic and epidemiological data on S. aureus isolated from mothers and babies in a randomized intra-partum azithromycin trial (PregnAnZI) to describe bacterial population dynamics and resistance mechanisms.<h4>Methods</h4>Participants from both arms of the trial, who carried S. aureus in day 3 and day 28 samples post-intervention, were included. Sixty-six S. aureus isolates (from 7 mothers and 10 babies) underwent comparative genome analyses and the data were then combined with epidemiological data. Trial registration (main trial): ClinicalT","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2026-04-08T02:08:19.04Z","creation":"2019-11-07T08:04:58Z"},"accession":"S-EPMC6798832","cross_references":{"pubmed":["31424550"],"doi":["10.1093/jac/dkz341"]}}