biostudies-literatureUnknown18(1)Hidalgo-Tenorio COBJECTIVES:To analyse the effectiveness of dalbavancin (DBV) in clinical practice as consolidation therapy in patients with bloodstream infection (BSI) and/or infective endocarditis (IE) produced by gram-positive cocci (GPC), as well as its safety and pharmacoeconomic impact. METHODS:A multicentre, observational and retrospective study was conducted of hospitalised patients with IE and/or BSI produced by GPC who received at least one dose of DBV. Clinical response was assessed during hospitalization, at 3 months and at 1 year. RESULTS:Eighty-three patients with median age of 73 years were enrolled; 73.5% were male; 59.04% had BSI and 49.04% IE (44.04% prosthetic valve IE, 32.4% native IE, 23.5% pacemaker lead). The most frequently isolated microorganism was Staphylococcus aureus in BSI (49Annals of clinical microbiology and antimicrobials30https://www.ebi.ac.uk/biostudies/studies/S-EPMC6800500biostudies-literatureDALBACEN cohort: dalbavancin as consolidation therapy in patients with endocarditis and/or bloodstream infection produced by gram-positive cocci.PMC6800500Herrero CSequera SIftimie SBereciartua EMunoz PMiro JMDe Jesus SEFernandez-Roldan CVinuesa DFarinas MCMartinez-Marcos FJHidalgo-Tenorio CMartin Davila PLoeches BLopez-Cortes LEPasquau JPlata AJavier-Martinez RArenas-Miras MDMfalseDALBACEN cohort: dalbavancin as consolidation therapy in patients with endocarditis and/or bloodstream infection produced by gram-positive cocci.OBJECTIVES:To analyse the effectiveness of dalbavancin (DBV) in clinical practice as consolidation therapy in patients with bloodstream infection (BSI) and/or infective endocarditis (IE) produced by gram-positive cocci (GPC), as well as its safety and pharmacoeconomic impact. METHODS:A multicentre, observational and retrospective study was conducted of hospitalised patients with IE and/or BSI produced by GPC who received at least one dose of DBV. Clinical response was assessed during hospitalization, at 3 months and at 1 year. RESULTS:Eighty-three patients with median age of 73 years were enrolled; 73.5% were male; 59.04% had BSI and 49.04% IE (44.04% prosthetic valve IE, 32.4% native IE, 23.5% pacemaker lead). The most frequently isolated microorganism was Staphylococcus aureus in BSI (492019-01-01T00:00:00Z2019 Oct2025-04-22T21:31:50.475Z2019-11-05T08:03:54ZS-EPMC68005003162940910.1186/s12941-019-0329-6