biostudies-literatureUnknown20(19)Vega-Bautista ALactoferrin (Lf) is an iron-binding milk glycoprotein that promotes the growth of selected probiotic strains. The effect of Lf on the growth and diversification of intestinal microbiota may have an impact on several issues, including (i) strengthening the permeability of the epithelial cell monolayer, (ii) favoring the microbial antagonism that discourages the colonization and proliferation of enteric pathogens, (iii) enhancing the growth and maturation of cell-monolayer components and gut nerve fibers, and (iv) providing signals to balance the anti- and pro-inflammatory responses resulting in gut homeostasis. Given the beneficial role of probiotics, this contribution aims to review the current properties of bovine and human Lf and their derivatives in in vitro probiotic growth and Lf inteInternational journal of molecular sciencesE4707https://www.ebi.ac.uk/biostudies/studies/S-EPMC6801499biostudies-literatureThe Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria.PMC6801499Carrero JCGodinez-Victoria MVega-Bautista ADrago-Serrano MECampos-Rodriguez Rde la Garza MfalseThe Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria.Lactoferrin (Lf) is an iron-binding milk glycoprotein that promotes the growth of selected probiotic strains. The effect of Lf on the growth and diversification of intestinal microbiota may have an impact on several issues, including (i) strengthening the permeability of the epithelial cell monolayer, (ii) favoring the microbial antagonism that discourages the colonization and proliferation of enteric pathogens, (iii) enhancing the growth and maturation of cell-monolayer components and gut nerve fibers, and (iv) providing signals to balance the anti- and pro-inflammatory responses resulting in gut homeostasis. Given the beneficial role of probiotics, this contribution aims to review the current properties of bovine and human Lf and their derivatives in in vitro probiotic growth and Lf inte2019-01-01T00:00:00Z2019 Sep2025-04-21T15:45:03.853Z2019-11-08T08:02:40ZS-EPMC68014993154757410.3390/ijms20194707