{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Su F"],"funding":["Annenberg Foundation"],"pagination":["E4807"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6801888"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(19)"],"pubmed_abstract":["Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of pathology in AMD. Oxidative stress plays a key role in the development of AMD. We generated a chimeric high-density lipoprotein (HDL), mimetic peptide named HM-10/10, with anti-oxidant properties and investigated its potential for the treatment of retinal disease using cell culture and animal models of RPE and photoreceptor (PR) degeneration. Treatment with HM-10/10 peptide prevented human fetal RPE cell death caused by tert-Butyl hydroperoxide (tBH)-induced oxidative stress and sodium iodate (NaIO3), which causes RPE atrophy and is a model of geographic atrophy in mice. We also show that HM-10/10 peptide ameliorated photoreceptor cell de"],"journal":["International journal of molecular sciences"],"pubmed_title":["A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration."],"pmcid":["PMC6801888"],"funding_grant_id":["FN# 49178"],"pubmed_authors":["Wang M","Hinton DR","Nusinowitz S","Kannan R","Farias-Eisner R","Araujo E","Reddy ST","Ghione C","Spee C","Barron E","Su F"],"additional_accession":[]},"is_claimable":false,"name":"A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration.","description":"Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of pathology in AMD. Oxidative stress plays a key role in the development of AMD. We generated a chimeric high-density lipoprotein (HDL), mimetic peptide named HM-10/10, with anti-oxidant properties and investigated its potential for the treatment of retinal disease using cell culture and animal models of RPE and photoreceptor (PR) degeneration. Treatment with HM-10/10 peptide prevented human fetal RPE cell death caused by tert-Butyl hydroperoxide (tBH)-induced oxidative stress and sodium iodate (NaIO3), which causes RPE atrophy and is a model of geographic atrophy in mice. We also show that HM-10/10 peptide ameliorated photoreceptor cell de","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-04-20T00:27:50.251Z","creation":"2019-11-07T08:05:16Z"},"accession":"S-EPMC6801888","cross_references":{"pubmed":["31569695"],"doi":["10.3390/ijms20194807"]}}