biostudies-literatureUnknown20(19)Blond FThe retina is the light sensitive part of the eye and nervous tissue that have been used extensively to characterize the function of the central nervous system. The retina has a central position both in fundamental biology and in the physiopathology of neurodegenerative diseases. We address the contribution of functional genomics to the understanding of retinal biology by reviewing key events in their historical perspective as an introduction to major findings that were obtained through the study of the retina using genomics, transcriptomics and proteomics. We illustrate our purpose by showing that most of the genes of interest for retinal development and those involved in inherited retinal degenerations have a restricted expression to the retina and most particularly to photoreceptors celInternational journal of molecular sciencesE4922https://www.ebi.ac.uk/biostudies/studies/S-EPMC6801968biostudies-literatureFunctional Genomics of the Retina to Elucidate its Construction and Deconstruction.PMC6801968Leveillard TBlond FfalseFunctional Genomics of the Retina to Elucidate its Construction and Deconstruction.The retina is the light sensitive part of the eye and nervous tissue that have been used extensively to characterize the function of the central nervous system. The retina has a central position both in fundamental biology and in the physiopathology of neurodegenerative diseases. We address the contribution of functional genomics to the understanding of retinal biology by reviewing key events in their historical perspective as an introduction to major findings that were obtained through the study of the retina using genomics, transcriptomics and proteomics. We illustrate our purpose by showing that most of the genes of interest for retinal development and those involved in inherited retinal degenerations have a restricted expression to the retina and most particularly to photoreceptors cel2019-01-01T00:00:00Z2019 Oct2025-05-31T23:16:48.415Z2020-11-08T09:37:34ZS-EPMC68019683159027710.3390/ijms20194922