{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dhaeze T"],"funding":["CIHR"],"pagination":["652-665"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6804668"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(7)"],"pubmed_abstract":["CD70 is the unique ligand of CD27 and is expressed on immune cells only upon activation. Therefore, engagement of the costimulatory CD27/CD70 pathway is solely dependent on upregulation of CD70. However, the T cell-intrinsic effect and function of human CD70 remain underexplored. Herein, we describe that CD70 expression distinguishes proinflammatory CD4<sup>+</sup> T lymphocytes that display an increased potential to migrate into the central nervous system (CNS). Upregulation of CD70 on CD4<sup>+</sup> T lymphocytes is induced by TGF-β1 and TGF-β3, which promote a pathogenic phenotype. In addition, CD70 is associated with a T<sub>H</sub>1 and T<sub>H</sub>17 profile of lymphocytes and is important for T-bet and IFN-γ expression by both T helper subtypes. Moreover, adoptive transfer of CD70"],"journal":["Cellular & molecular immunology"],"pubmed_title":["CD70 defines a subset of proinflammatory and CNS-pathogenic T<sub>H</sub>1/T<sub>H</sub>17 lymphocytes and is overexpressed in multiple sclerosis."],"pmcid":["PMC6804668"],"funding_grant_id":["PJI-153195","MOP 89885"],"pubmed_authors":["Dhaeze T","Ayrignac X","Prat A","Peelen E","Grasmuck C","Larochelle C","Girard M","Moumdjian R","Rebillard RM","Poirier J","Lahav B","Bouthillier A","Larouche S","Lachance C","Zandee S","Duquette P","Bourbonniere L","Tremblay L"],"additional_accession":[]},"is_claimable":false,"name":"CD70 defines a subset of proinflammatory and CNS-pathogenic T<sub>H</sub>1/T<sub>H</sub>17 lymphocytes and is overexpressed in multiple sclerosis.","description":"CD70 is the unique ligand of CD27 and is expressed on immune cells only upon activation. Therefore, engagement of the costimulatory CD27/CD70 pathway is solely dependent on upregulation of CD70. However, the T cell-intrinsic effect and function of human CD70 remain underexplored. Herein, we describe that CD70 expression distinguishes proinflammatory CD4<sup>+</sup> T lymphocytes that display an increased potential to migrate into the central nervous system (CNS). Upregulation of CD70 on CD4<sup>+</sup> T lymphocytes is induced by TGF-β1 and TGF-β3, which promote a pathogenic phenotype. In addition, CD70 is associated with a T<sub>H</sub>1 and T<sub>H</sub>17 profile of lymphocytes and is important for T-bet and IFN-γ expression by both T helper subtypes. Moreover, adoptive transfer of CD70","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jul","modification":"2025-04-19T03:38:11.258Z","creation":"2020-07-04T07:18:36Z"},"accession":"S-EPMC6804668","cross_references":{"pubmed":["30635649"],"doi":["10.1038/s41423-018-0198-5"]}}