{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luo J"],"funding":["Science and Technology Commission of Shanghai Municipality","National Natural Science Foundation of China"],"pagination":["19"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6804689"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7"],"pubmed_abstract":["The superfamily of G protein-coupled receptors (GPCRs) contains immense structural and functional diversity and mediates a myriad of biological processes upon activation by various extracellular signals. Critical roles of GPCRs have been established in bone development, remodeling, and disease. Multiple human GPCR mutations impair bone development or metabolism, resulting in osteopathologies. Here we summarize the disease phenotypes and dysfunctions caused by GPCR gene mutations in humans as well as by deletion in animals. To date, 92 receptors (5 glutamate family, 67 rhodopsin family, 5 adhesion, 4 frizzled/taste2 family, 5 secretin family, and 6 other 7TM receptors) have been associated with bone diseases and dysfunctions (36 in humans and 72 in animals). By analyzing data from these 92 "],"journal":["Bone research"],"pubmed_title":["The role of GPCRs in bone diseases and dysfunctions."],"pmcid":["PMC6804689"],"funding_grant_id":["81330059, 81572640","81330049","17JC1400903, 17411950300","81722020, 91749204, 81472048"],"pubmed_authors":["Sun P","Luo J","Liu M","Xiao J","Siwko S"],"additional_accession":[]},"is_claimable":false,"name":"The role of GPCRs in bone diseases and dysfunctions.","description":"The superfamily of G protein-coupled receptors (GPCRs) contains immense structural and functional diversity and mediates a myriad of biological processes upon activation by various extracellular signals. Critical roles of GPCRs have been established in bone development, remodeling, and disease. Multiple human GPCR mutations impair bone development or metabolism, resulting in osteopathologies. Here we summarize the disease phenotypes and dysfunctions caused by GPCR gene mutations in humans as well as by deletion in animals. To date, 92 receptors (5 glutamate family, 67 rhodopsin family, 5 adhesion, 4 frizzled/taste2 family, 5 secretin family, and 6 other 7TM receptors) have been associated with bone diseases and dysfunctions (36 in humans and 72 in animals). By analyzing data from these 92 ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-22T00:39:03.146Z","creation":"2019-11-05T08:12:00Z"},"accession":"S-EPMC6804689","cross_references":{"pubmed":["31646011"],"doi":["10.1038/s41413-019-0059-6"]}}