{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19"],"submitter":["Yu GJ"],"pubmed_abstract":["<h4>Background</h4>LncRNAs may exert a regulatory effect in tumorigenesis. Although the expression of lncRNA <i>HOTAIR</i> has been confirmed to be notably elevated in the tissues of CSCC, its biological mechanism in CSCC is still unknown.<h4>Methods</h4><i>HOTAIR</i> expression level in CSCC cell lines was monitored via qRT-PCR. Then CCK-8 assay, Transwell assay and EdU assay were adopted to detect cell migration and proliferation. Meanwhile, through bioinformatics analysis and luciferase reporter gene detection, a new target of <i>HOTAIR</i> was identified. Additionally, Western blotting and RIP analysis were adopted to discuss the possible mechanism.<h4>Results</h4><i>HOTAIR</i> expression in CSCC cell lines exhibited an obvious elevation. Cell function analysis revealed that <i>HOTAIR<"],"journal":["Cancer cell international"],"pagination":["270"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6805682"],"repository":["biostudies-literature"],"pubmed_title":["Long non-coding RNA HOTAIR functions as a competitive endogenous RNA to regulate PRAF2 expression by sponging miR-326 in cutaneous squamous cell carcinoma."],"pmcid":["PMC6805682"],"pubmed_authors":["Zhang DW","Yu GJ","Sun Y","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"Long non-coding RNA HOTAIR functions as a competitive endogenous RNA to regulate PRAF2 expression by sponging miR-326 in cutaneous squamous cell carcinoma.","description":"<h4>Background</h4>LncRNAs may exert a regulatory effect in tumorigenesis. Although the expression of lncRNA <i>HOTAIR</i> has been confirmed to be notably elevated in the tissues of CSCC, its biological mechanism in CSCC is still unknown.<h4>Methods</h4><i>HOTAIR</i> expression level in CSCC cell lines was monitored via qRT-PCR. Then CCK-8 assay, Transwell assay and EdU assay were adopted to detect cell migration and proliferation. Meanwhile, through bioinformatics analysis and luciferase reporter gene detection, a new target of <i>HOTAIR</i> was identified. Additionally, Western blotting and RIP analysis were adopted to discuss the possible mechanism.<h4>Results</h4><i>HOTAIR</i> expression in CSCC cell lines exhibited an obvious elevation. Cell function analysis revealed that <i>HOTAIR<","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-06-01T01:14:48.001Z","creation":"2025-06-01T01:14:48.001Z"},"accession":"S-EPMC6805682","cross_references":{"pubmed":["31649487"],"doi":["10.1186/s12935-019-0992-x"]}}