{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang J"],"funding":["Natural Sciences and Engineering Research Council of Canada","Fundamental Research Funds for the Central Universities","National Key R&amp;D Program of China","111 Project","National Natural Science Foundation of China","State Key Laboratory of Bioreactor Engineering"],"pagination":["173-179"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6807035"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(4)"],"pubmed_abstract":["Microbes serve as the most important resource for drug discovery. During our screening for bioactive compounds from our natural products library, a pathogenic fungus, <i>Microdochium majus</i> strain 99049, from wheat was selected for further investigation. A new alkaloid named brocaeloid D (<b>1</b>), together with six previously characterized compounds (<b>2</b>-<b>7</b>) were identified. Compound <b>1</b> belongs to 4-oxoquinoline with C-2 reversed prenylation and a succinimide substructure. All the structures of these newly isolated compounds were determined by different means in spectroscopic experiments. The absolute configurations of <b>1</b> was further deduced from comparison of its CD spectrum with that of known compound <b>2</b>. The bioactivities of these identified compounds w"],"journal":["Synthetic and systems biotechnology"],"pubmed_title":["Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, <i>Microdochium majus</i> 99049."],"pmcid":["PMC6807035"],"funding_grant_id":["21877038","31430002","31320103911","2017YFE0108200","81573341","B18022","31720103901","22221818014"],"pubmed_authors":["Ma R","Jiang L","Zhang J","Hsiang T","Zhu G","Zhang L","Li L","Liu X","Hou C","Han J","Wang Z","Song Z","Karthik L"],"additional_accession":[]},"is_claimable":false,"name":"Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, <i>Microdochium majus</i> 99049.","description":"Microbes serve as the most important resource for drug discovery. During our screening for bioactive compounds from our natural products library, a pathogenic fungus, <i>Microdochium majus</i> strain 99049, from wheat was selected for further investigation. A new alkaloid named brocaeloid D (<b>1</b>), together with six previously characterized compounds (<b>2</b>-<b>7</b>) were identified. Compound <b>1</b> belongs to 4-oxoquinoline with C-2 reversed prenylation and a succinimide substructure. All the structures of these newly isolated compounds were determined by different means in spectroscopic experiments. The absolute configurations of <b>1</b> was further deduced from comparison of its CD spectrum with that of known compound <b>2</b>. The bioactivities of these identified compounds w","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2026-05-04T17:13:21.074Z","creation":"2019-11-07T08:05:38Z"},"accession":"S-EPMC6807035","cross_references":{"pubmed":["31667367"],"doi":["10.1016/j.synbio.2019.09.001"]}}