{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(6)"],"submitter":["Zhan X"],"pubmed_abstract":["BACKGROUND:Rs11614913 is a polymorphism in hsa-miR-196a2 reported to alter mature microRNA expression and function. This single-nucleotide polymorphism (SNP) was reported to be associated with susceptibility and prognosis of lung cancer. METHODS:In this article, association study was performed to reveal the relation between SNP and response rate or severe toxicity after platinum-based regimen in advanced nonsmall cell lung cancer patients. RESULTS:By screening this polymorphism in 442 Chinese patients with MALDI-TOF Mass Spectrometer, significantly higher occurrence of grade 3 or 4 overall toxicity (P = 0.02) in response to treatment was found in patients with homozygous CC. After stratified analyses, association between rs11614912 and overall toxicity existed, especially in individuals treated with gemcitabine (P = 0.006) or cisplatin (P = 0.008), and in male patients (P = 0.02) or younger patients (P = 0.01). CONCLUSION:Our study confirmed that rs11614913 in hsa-miR-196a2 was associated with severe toxicity in lung cancer patients, and might help to improve individualized therapy in the future."],"journal":["Journal of clinical laboratory analysis"],"pagination":["441-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6807410"],"repository":["biostudies-literature"],"pubmed_title":["Hsa-miR-196a2 functional SNP is associated with severe toxicity after platinum-based chemotherapy of advanced nonsmall cell lung cancer patients in a Chinese population."],"pmcid":["PMC6807410"],"pubmed_authors":["Fan W","Shen J","Wu Q","Zhan X","Lu D","Gao G","Chen H","Zhang S","Gu A","Lv J","Zhang W","Han B","Zhang T","Qiao R","Wu W"],"additional_accession":[]},"is_claimable":false,"name":"Hsa-miR-196a2 functional SNP is associated with severe toxicity after platinum-based chemotherapy of advanced nonsmall cell lung cancer patients in a Chinese population.","description":"BACKGROUND:Rs11614913 is a polymorphism in hsa-miR-196a2 reported to alter mature microRNA expression and function. This single-nucleotide polymorphism (SNP) was reported to be associated with susceptibility and prognosis of lung cancer. METHODS:In this article, association study was performed to reveal the relation between SNP and response rate or severe toxicity after platinum-based regimen in advanced nonsmall cell lung cancer patients. RESULTS:By screening this polymorphism in 442 Chinese patients with MALDI-TOF Mass Spectrometer, significantly higher occurrence of grade 3 or 4 overall toxicity (P = 0.02) in response to treatment was found in patients with homozygous CC. After stratified analyses, association between rs11614912 and overall toxicity existed, especially in individuals treated with gemcitabine (P = 0.006) or cisplatin (P = 0.008), and in male patients (P = 0.02) or younger patients (P = 0.01). CONCLUSION:Our study confirmed that rs11614913 in hsa-miR-196a2 was associated with severe toxicity in lung cancer patients, and might help to improve individualized therapy in the future.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Nov","modification":"2020-11-19T12:56:53Z","creation":"2020-05-21T18:22:53Z"},"accession":"S-EPMC6807410","cross_references":{"pubmed":["23143626"],"doi":["10.1002/jcla.21544"]}}