{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(Suppl 2)"],"submitter":["Levast B"],"pubmed_abstract":["Abstract Background
There is growing interest about the deleterious impact of antibiotics on loss of gut symbiosis, called dysbiosis. As patients with BJI require antibiotics usually during 6 to 12 weeks, it is of interest to determine whether dysbiosis is frequent in this population, and if it could potentially reversible or not. Methods
Multicentric prospective cohort study in France (EudraCT 2016-003247-10) including patients with 3 categories of BJI: native, osteosynthesis-related and prosthetic joint infection (PJI). At the time of suspicion (V1), at the end of therapy (V2) and then 2 weeks after stopping therapy (V3), blood and fecal samples were collected. Extracted DNA from stool was sequenced using shotgun metagenomic sequencing based on illumina library and Iseq"],"journal":["Open forum infectious diseases"],"pagination":["S896-S896"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6810693"],"repository":["biostudies-literature"],"pubmed_title":["2579. Impact on the Gut Microbiota of the Prolonged Antimicrobial Therapy in Patients with Bone and Joint Infection (BJI): Results From the OSIRIS Prospective Study in France"],"pmcid":["PMC6810693"],"pubmed_authors":["Levast B","Boutoille D","Zeller V","Batailler C","Senneville E","Dauchy F","Pouderoux C","Ferry T","Lustig S","Laurent F","Maynard M","Boucihna L"],"additional_accession":[]},"is_claimable":false,"name":"2579. Impact on the Gut Microbiota of the Prolonged Antimicrobial Therapy in Patients with Bone and Joint Infection (BJI): Results From the OSIRIS Prospective Study in France","description":"Abstract Background
There is growing interest about the deleterious impact of antibiotics on loss of gut symbiosis, called dysbiosis. As patients with BJI require antibiotics usually during 6 to 12 weeks, it is of interest to determine whether dysbiosis is frequent in this population, and if it could potentially reversible or not. Methods
Multicentric prospective cohort study in France (EudraCT 2016-003247-10) including patients with 3 categories of BJI: native, osteosynthesis-related and prosthetic joint infection (PJI). At the time of suspicion (V1), at the end of therapy (V2) and then 2 weeks after stopping therapy (V3), blood and fecal samples were collected. Extracted DNA from stool was sequenced using shotgun metagenomic sequencing based on illumina library and Iseq","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2025-04-26T06:43:17.699Z","creation":"2019-11-07T08:08:50Z"},"accession":"S-EPMC6810693","cross_references":{}}