{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(10)"],"submitter":["Saeed-Zidane M"],"pubmed_abstract":["Focal adhesion pathway is one of the key molecular pathways affected by suboptimal culture conditions during embryonic development. The epidermal growth factor (EGF) and hyaluronic acid (HA) are believed to be involved in the focal adhesion pathway function by regulating the adherence of the molecules to the extracellular matrix. However, regulatory and molecular mechanisms through which the EGF and HA could influence the embryo development is not clear. Therefore, this study aimed to investigate the effect of continued or stage specific supplementation of EGF and/or HA on the developmental competence and quality of bovine preimplantation embryos and the subsequent consequences on the expression and DNA methylation patterns of genes involved in the focal adhesion pathway. The results revea"],"journal":["PloS one"],"pagination":["e0223753"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6818761"],"repository":["biostudies-literature"],"pubmed_title":["Hyaluronic acid and epidermal growth factor improved the bovine embryo quality by regulating the DNA methylation and expression patterns of the focal adhesion pathway."],"pmcid":["PMC6818761"],"pubmed_authors":["Hoelker M","Schellander K","Rings F","Held E","Neuhoff C","Salilew-Wondim D","Mohammed Shaker Y","Tesfaye D","Tholen E","Saeed-Zidane M"],"additional_accession":[]},"is_claimable":false,"name":"Hyaluronic acid and epidermal growth factor improved the bovine embryo quality by regulating the DNA methylation and expression patterns of the focal adhesion pathway.","description":"Focal adhesion pathway is one of the key molecular pathways affected by suboptimal culture conditions during embryonic development. The epidermal growth factor (EGF) and hyaluronic acid (HA) are believed to be involved in the focal adhesion pathway function by regulating the adherence of the molecules to the extracellular matrix. However, regulatory and molecular mechanisms through which the EGF and HA could influence the embryo development is not clear. Therefore, this study aimed to investigate the effect of continued or stage specific supplementation of EGF and/or HA on the developmental competence and quality of bovine preimplantation embryos and the subsequent consequences on the expression and DNA methylation patterns of genes involved in the focal adhesion pathway. The results revea","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-27T00:51:44.315Z","creation":"2020-11-19T13:24:23Z"},"accession":"S-EPMC6818761","cross_references":{"pubmed":["31661494"],"doi":["10.1371/journal.pone.0223753"]}}