{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xia C"],"funding":["NIDDK NIH HHS","NIEHS NIH HHS"],"pagination":["2434-2447"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6821582"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(12)"],"pubmed_abstract":["<h4>Objective</h4>Myeloid-related protein-14 (MRP14) and its binding partner MRP8 play an essential role in innate immune function and have been implicated in a variety of inflammatory diseases. However, the role of MRP14 in obesity-induced inflammation and insulin resistance is not well defined. This study investigated the role of MRP14 in macrophage-mediated adipose tissue inflammation and obesity-induced insulin resistance.<h4>Subjects and results</h4>Wild-type (WT) and Mrp14<sup>-/-</sup> mice were fed with a high-fat diet or normal chow for 12 weeks. Tissue-resident macrophages in both adipose tissue and liver from obese WT mice expressed higher levels of MRP14 in the visceral adipose fat and liver compared with the lean mice. Mrp14<sup>-/-</sup> mice demonstrated a significantly impr"],"journal":["International journal of obesity (2005)"],"pubmed_title":["MRP14 enhances the ability of macrophage to recruit T cells and promotes obesity-induced insulin resistance."],"pmcid":["PMC6821582"],"funding_grant_id":["R00 ES026241","K99 ES026241","K01 DK105108"],"pubmed_authors":["Simon DI","Toomey AC","Zhao S","Rajagopalan S","Braunstein Z","Rao X","Mao H","Xia C","Razavi M","Wang Y","Zhong J"],"additional_accession":[]},"is_claimable":false,"name":"MRP14 enhances the ability of macrophage to recruit T cells and promotes obesity-induced insulin resistance.","description":"<h4>Objective</h4>Myeloid-related protein-14 (MRP14) and its binding partner MRP8 play an essential role in innate immune function and have been implicated in a variety of inflammatory diseases. However, the role of MRP14 in obesity-induced inflammation and insulin resistance is not well defined. This study investigated the role of MRP14 in macrophage-mediated adipose tissue inflammation and obesity-induced insulin resistance.<h4>Subjects and results</h4>Wild-type (WT) and Mrp14<sup>-/-</sup> mice were fed with a high-fat diet or normal chow for 12 weeks. Tissue-resident macrophages in both adipose tissue and liver from obese WT mice expressed higher levels of MRP14 in the visceral adipose fat and liver compared with the lean mice. Mrp14<sup>-/-</sup> mice demonstrated a significantly impr","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-04-04T12:17:56.555Z","creation":"2019-11-09T08:01:42Z"},"accession":"S-EPMC6821582","cross_references":{"pubmed":["31040394"],"doi":["10.1038/s41366-019-0366-4"]}}