biostudies-literatureXia CNIDDK NIH HHSNIEHS NIH HHS2434-2447https://www.ebi.ac.uk/biostudies/studies/S-EPMC6821582biostudies-literatureUnknown43(12)<h4>Objective</h4>Myeloid-related protein-14 (MRP14) and its binding partner MRP8 play an essential role in innate immune function and have been implicated in a variety of inflammatory diseases. However, the role of MRP14 in obesity-induced inflammation and insulin resistance is not well defined. This study investigated the role of MRP14 in macrophage-mediated adipose tissue inflammation and obesity-induced insulin resistance.<h4>Subjects and results</h4>Wild-type (WT) and Mrp14^-/- mice were fed with a high-fat diet or normal chow for 12 weeks. Tissue-resident macrophages in both adipose tissue and liver from obese WT mice expressed higher levels of MRP14 in the visceral adipose fat and liver compared with the lean mice. Mrp14^-/- mice demonstrated a significantly imprInternational journal of obesity (2005)MRP14 enhances the ability of macrophage to recruit T cells and promotes obesity-induced insulin resistance.PMC6821582R00 ES026241K99 ES026241K01 DK105108Simon DIToomey ACZhao SRajagopalan SBraunstein ZRao XMao HXia CRazavi MWang YZhong JfalseMRP14 enhances the ability of macrophage to recruit T cells and promotes obesity-induced insulin resistance.<h4>Objective</h4>Myeloid-related protein-14 (MRP14) and its binding partner MRP8 play an essential role in innate immune function and have been implicated in a variety of inflammatory diseases. However, the role of MRP14 in obesity-induced inflammation and insulin resistance is not well defined. This study investigated the role of MRP14 in macrophage-mediated adipose tissue inflammation and obesity-induced insulin resistance.<h4>Subjects and results</h4>Wild-type (WT) and Mrp14^-/- mice were fed with a high-fat diet or normal chow for 12 weeks. Tissue-resident macrophages in both adipose tissue and liver from obese WT mice expressed higher levels of MRP14 in the visceral adipose fat and liver compared with the lean mice. Mrp14^-/- mice demonstrated a significantly impr2019-01-01T00:00:00Z2019 Dec2025-04-04T12:17:56.555Z2019-11-09T08:01:42ZS-EPMC68215823104039410.1038/s41366-019-0366-4