{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vaske OM"],"funding":["Howard Hughes Medical Institute","NHGRI NIH HHS","NCI NIH HHS"],"pagination":["e1913968"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6822083"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(10)"],"pubmed_abstract":["<h4>Importance</h4>Pediatric cancers are epigenetic diseases; therefore, considering tumor gene expression information is necessary for a complete understanding of the tumorigenic processes.<h4>Objective</h4>To evaluate the feasibility and utility of incorporating comparative gene expression information into the precision medicine framework for difficult-to-treat pediatric and young adult patients with cancer.<h4>Design, setting, and participants</h4>This cohort study was conducted as a consortium between the University of California, Santa Cruz (UCSC) Treehouse Childhood Cancer Initiative and clinical genomic trials. RNA sequencing (RNA-Seq) data were obtained from the following 4 clinical sites and analyzed at UCSC: British Columbia Children's Hospital (n = 31), Lucile Packard Children's"],"journal":["JAMA network open"],"pubmed_title":["Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer."],"pmcid":["PMC6822083"],"funding_grant_id":["U24 CA210974","U24 CA195858","T32 HG008345","U24 CA180951"],"pubmed_authors":["Durbin A","McColl D","Beale H","Byron SA","Tayi Shah A","Learned K","Spillinger A","Currie R","Lam DL","Torno L","Leung SG","Newton Y","Liu HY","Resnick AC","Laskin J","Marra MA","Goldstein TC","Huynh V","Deyell RJ","Rassekh SR","Swatloski T","Pfeil J","Kirov I","Zabokrtsky KB","Lacayo N","Berens ME","Plant A","Bjork I","Haussler D","Vaske OM","Sender LS","Kephart ET","Sweet-Cordero EA","Zhu J","Liang WS","Sanders L","Lee AG","Vivian J","Mueller S","Salama SR","Spunt SL","Rangaswami A"],"additional_accession":[]},"is_claimable":false,"name":"Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer.","description":"<h4>Importance</h4>Pediatric cancers are epigenetic diseases; therefore, considering tumor gene expression information is necessary for a complete understanding of the tumorigenic processes.<h4>Objective</h4>To evaluate the feasibility and utility of incorporating comparative gene expression information into the precision medicine framework for difficult-to-treat pediatric and young adult patients with cancer.<h4>Design, setting, and participants</h4>This cohort study was conducted as a consortium between the University of California, Santa Cruz (UCSC) Treehouse Childhood Cancer Initiative and clinical genomic trials. RNA sequencing (RNA-Seq) data were obtained from the following 4 clinical sites and analyzed at UCSC: British Columbia Children's Hospital (n = 31), Lucile Packard Children's","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2026-04-16T13:10:47.208Z","creation":"2020-05-21T18:49:56Z"},"accession":"S-EPMC6822083","cross_references":{"pubmed":["31651965"],"doi":["10.1001/jamanetworkopen.2019.13968"]}}