biostudies-literatureVaske OMHoward Hughes Medical InstituteNHGRI NIH HHSNCI NIH HHSe1913968https://www.ebi.ac.uk/biostudies/studies/S-EPMC6822083biostudies-literatureUnknown2(10)<h4>Importance</h4>Pediatric cancers are epigenetic diseases; therefore, considering tumor gene expression information is necessary for a complete understanding of the tumorigenic processes.<h4>Objective</h4>To evaluate the feasibility and utility of incorporating comparative gene expression information into the precision medicine framework for difficult-to-treat pediatric and young adult patients with cancer.<h4>Design, setting, and participants</h4>This cohort study was conducted as a consortium between the University of California, Santa Cruz (UCSC) Treehouse Childhood Cancer Initiative and clinical genomic trials. RNA sequencing (RNA-Seq) data were obtained from the following 4 clinical sites and analyzed at UCSC: British Columbia Children's Hospital (n = 31), Lucile Packard Children'sJAMA network openComparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer.PMC6822083U24 CA210974U24 CA195858T32 HG008345U24 CA180951Durbin AMcColl DBeale HByron SATayi Shah ALearned KSpillinger ACurrie RLam DLTorno LLeung SGNewton YLiu HYResnick ACLaskin JMarra MAGoldstein TCHuynh VDeyell RJRassekh SRSwatloski TPfeil JKirov IZabokrtsky KBLacayo NBerens MEPlant ABjork IHaussler DVaske OMSender LSKephart ETSweet-Cordero EAZhu JLiang WSSanders LLee AGVivian JMueller SSalama SRSpunt SLRangaswami AfalseComparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer.<h4>Importance</h4>Pediatric cancers are epigenetic diseases; therefore, considering tumor gene expression information is necessary for a complete understanding of the tumorigenic processes.<h4>Objective</h4>To evaluate the feasibility and utility of incorporating comparative gene expression information into the precision medicine framework for difficult-to-treat pediatric and young adult patients with cancer.<h4>Design, setting, and participants</h4>This cohort study was conducted as a consortium between the University of California, Santa Cruz (UCSC) Treehouse Childhood Cancer Initiative and clinical genomic trials. RNA sequencing (RNA-Seq) data were obtained from the following 4 clinical sites and analyzed at UCSC: British Columbia Children's Hospital (n = 31), Lucile Packard Children's2019-01-01T00:00:00Z2019 Oct2026-04-16T13:10:47.208Z2020-05-21T18:49:56ZS-EPMC68220833165196510.1001/jamanetworkopen.2019.13968