{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li C"],"funding":["Military Major Special Project of PLA, China","Key Logistics Research Projects of PLA, China"],"pagination":["e7943"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6822597"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7"],"pubmed_abstract":["In the Chinese Han population, prolonged exposure to hypoxic conditions can promote compensatory erythropoiesis which improves hypoxemia. However, Tibetans have developed unique phenotypes, such as downregulation of the hypoxia-inducible factor pathway through EPAS1 gene mutation, thus the mechanism of adaption of the Han population should be further studied. The results indicated that, under plateau hypoxic conditions, the plains population was able to acclimate rapidly to hypoxia through increasing EPAS1 mRNA expression and changing the hemoglobin conformation. Furthermore, the mutant genotype frequencies of the rs13419896, rs1868092 and rs4953354 loci in the EPAS1 gene were significantly higher in the Tibetan population than in the plains population. The EPAS1 gene expression level was "],"journal":["PeerJ"],"pubmed_title":["Genetic changes in the EPAS1 gene between Tibetan and Han ethnic groups and adaptation to the plateau hypoxic environment."],"pmcid":["PMC6822597"],"funding_grant_id":["AWS13J004","BWS16J006-03-01"],"pubmed_authors":["Li X","Fan F","Liu J","Fan X","Li C","Xiao J","Lei H"],"additional_accession":[]},"is_claimable":false,"name":"Genetic changes in the EPAS1 gene between Tibetan and Han ethnic groups and adaptation to the plateau hypoxic environment.","description":"In the Chinese Han population, prolonged exposure to hypoxic conditions can promote compensatory erythropoiesis which improves hypoxemia. However, Tibetans have developed unique phenotypes, such as downregulation of the hypoxia-inducible factor pathway through EPAS1 gene mutation, thus the mechanism of adaption of the Han population should be further studied. The results indicated that, under plateau hypoxic conditions, the plains population was able to acclimate rapidly to hypoxia through increasing EPAS1 mRNA expression and changing the hemoglobin conformation. Furthermore, the mutant genotype frequencies of the rs13419896, rs1868092 and rs4953354 loci in the EPAS1 gene were significantly higher in the Tibetan population than in the plains population. The EPAS1 gene expression level was ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-22T00:03:28.886Z","creation":"2019-11-13T08:04:31Z"},"accession":"S-EPMC6822597","cross_references":{"pubmed":["31681516"],"doi":["10.7717/peerj.7943"]}}