{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bocharnikov AV"],"funding":["NIAMS","Rheumatology Research Foundation","Burroughs Wellcome Fund","Lupus Research Alliance","NIAMS NIH HHS"],"pagination":["130062"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6824311"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(20)"],"pubmed_abstract":["Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathologic T cell-B cell interactions and autoantibody production. Defining the T cell populations that drive B cell responses in SLE may enable design of therapies that specifically target pathologic cell subsets. Here, we evaluated the phenotypes of CD4+ T cells in the circulation of 52 SLE patients drawn from multiple cohorts and identified a highly expanded PD-1hiCXCR5-CD4+ T cell population. Cytometric, transcriptomic, and functional assays demonstrated that PD-1hiCXCR5-CD4+ T cells from SLE patients are T peripheral helper (Tph) cells, a CXCR5- T cell population that stimulates B cell responses via IL-21. The frequency of Tph cells, but not T follicular helper (Tfh) cells, correlated with both clinical disea"],"journal":["JCI insight"],"pubmed_title":["PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21."],"pmcid":["PMC6824311"],"funding_grant_id":["Career Award in Medical Sciences","R01 AR065538","Scientist Development Award","UH2 AR067679","AR072791","AR065538","AR070253","P30 AR070253","K08 AR072791","Target Identification in Lupus"],"pubmed_authors":["Wacleche VS","Wofsy D","Diamond B","Gurish MF","Petri M","Wang G","Guthridge JM","Li ZJ","Arazi A","Buyon JP","Keras G","Lederer JA","Muise ES","Qu Y","Accelerating Medicines Partnership (AMP) RA/SLE Network","Costenbader KH","James JA","Mackey MF","Rao DA","Anolik JH","Nigrovic PA","Fonseka CY","Keegan J","Zhang KX","Alves SE","Putterman C","Brenner MB","Cao Y","Bocharnikov AV"],"additional_accession":[]},"is_claimable":false,"name":"PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21.","description":"Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathologic T cell-B cell interactions and autoantibody production. Defining the T cell populations that drive B cell responses in SLE may enable design of therapies that specifically target pathologic cell subsets. Here, we evaluated the phenotypes of CD4+ T cells in the circulation of 52 SLE patients drawn from multiple cohorts and identified a highly expanded PD-1hiCXCR5-CD4+ T cell population. Cytometric, transcriptomic, and functional assays demonstrated that PD-1hiCXCR5-CD4+ T cells from SLE patients are T peripheral helper (Tph) cells, a CXCR5- T cell population that stimulates B cell responses via IL-21. The frequency of Tph cells, but not T follicular helper (Tfh) cells, correlated with both clinical disea","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2025-04-05T13:31:09.299Z","creation":"2019-11-15T08:04:51Z"},"accession":"S-EPMC6824311","cross_references":{"pubmed":["31536480"],"doi":["10.1172/jci.insight.130062"]}}