{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(10)"],"submitter":["Chen PC"],"pubmed_abstract":["MicroRNAs (miRNAs) have been shown to play a crucial role in the progression of human cancers, including urothelial carcinoma (UC), the sixth-most common cancer in the world. Among them, miR-34a has been implicated in the regulation of cancer stem cells (CSCs); however, its role in UC has yet to be fully elucidated. In this study, bioinformatics and experimental analysis confirmed that miR-34a targets CD44 (a CSC surface marker) and c-Myc (a well-known cell cycle regulator) in UC. We found that, surprisingly, most UC cell lines and patient samples did express miR-34a, although epigenetic silencing by promoter hypermethylation of miR-34a expression was observed only in UMUC3 cells, and a subset of patient samples. Importantly, overexpression of c-Myc, a frequently amplified oncogene in UC, "],"journal":["Cancers"],"pagination":["E1457"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6826510"],"repository":["biostudies-literature"],"pubmed_title":["c-Myc Acts as a Competing Endogenous RNA to Sponge miR-34a, in the Upregulation of CD44, in Urothelial Carcinoma."],"pmcid":["PMC6826510"],"pubmed_authors":["Jou YC","Huang WY","Huang WH","Chuang YM","Shen CH","Lin HY","Chan MWY","Lin RI","Lin JMJ","Chen PC","Yu CC"],"additional_accession":[]},"is_claimable":false,"name":"c-Myc Acts as a Competing Endogenous RNA to Sponge miR-34a, in the Upregulation of CD44, in Urothelial Carcinoma.","description":"MicroRNAs (miRNAs) have been shown to play a crucial role in the progression of human cancers, including urothelial carcinoma (UC), the sixth-most common cancer in the world. Among them, miR-34a has been implicated in the regulation of cancer stem cells (CSCs); however, its role in UC has yet to be fully elucidated. In this study, bioinformatics and experimental analysis confirmed that miR-34a targets CD44 (a CSC surface marker) and c-Myc (a well-known cell cycle regulator) in UC. We found that, surprisingly, most UC cell lines and patient samples did express miR-34a, although epigenetic silencing by promoter hypermethylation of miR-34a expression was observed only in UMUC3 cells, and a subset of patient samples. Importantly, overexpression of c-Myc, a frequently amplified oncogene in UC, ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-04-05T00:43:51.951Z","creation":"2020-05-21T19:57:29Z"},"accession":"S-EPMC6826510","cross_references":{"pubmed":["31569404"],"doi":["10.3390/cancers11101457"]}}