biostudies-literatureLiu YNIBIB NIH HHS1293-1302https://www.ebi.ac.uk/biostudies/studies/S-EPMC6826862biostudies-literatureUnknown11(15)Brain tumors present unique therapeutic challenges and they include glioblastoma (GBM) and metastases from cancers of other organs. Current treatment options are limited and include surgical resection, radiation therapy, laser interstitial thermal therapy and chemotherapy. Although much research has been done on the development of immune-based treatment platforms, only limited success has been demonstrated. Herein, we demonstrate a novel treatment of GBM through the use of plasmonic gold nanostars (GNS) as photothermal inducers for synergistic immuno photothermal nanotherapy (SYMPHONY), which combines treatments using gold nanostar and laser-induced photothermal therapy with checkpoint blockade immunotherapy. In the treatment of a murine flank tumor model with the CT-2A glioma cell line, SYMPHONY demonstrated the capability of producing long-term survivors that rejects rechallenge with cancer cells, heralding the successful emergence of immunologic memory. This study is the first to investigate the use of this novel therapy for the treatment of GBM in a murine model.ImmunotherapyPlasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory.PMC6826862R01 EB028078Maccarini PFLiu YFecci PEKemeny HRLascola CDCrawford BMOdion RCui XDechant CAVo-Dinh TChongsathidkiet PfalsePlasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory.Brain tumors present unique therapeutic challenges and they include glioblastoma (GBM) and metastases from cancers of other organs. Current treatment options are limited and include surgical resection, radiation therapy, laser interstitial thermal therapy and chemotherapy. Although much research has been done on the development of immune-based treatment platforms, only limited success has been demonstrated. Herein, we demonstrate a novel treatment of GBM through the use of plasmonic gold nanostars (GNS) as photothermal inducers for synergistic immuno photothermal nanotherapy (SYMPHONY), which combines treatments using gold nanostar and laser-induced photothermal therapy with checkpoint blockade immunotherapy. In the treatment of a murine flank tumor model with the CT-2A glioma cell line, SYMPHONY demonstrated the capability of producing long-term survivors that rejects rechallenge with cancer cells, heralding the successful emergence of immunologic memory. This study is the first to investigate the use of this novel therapy for the treatment of GBM in a murine model.2019-01-01T00:00:00Z2019 Oct2025-04-19T04:31:32.303Z2025-04-19T04:31:32.303ZS-EPMC68268623153020010.2217/imt-2019-0023