biostudies-literature00480Haydl AMNIGMS NIH HHS1337-1341https://www.ebi.ac.uk/biostudies/studies/S-EPMC6827334biostudies-literatureUnknown21(5)A method for the direct methylation of aryl, heteroaryl, and vinyl boronate esters is reported, involving the reaction of iodomethane with aryl-, heteroaryl-, and vinylboronate esters catalyzed by palladium and PtBu2Me. This transformation occurs with a remarkably broad scope and is suitable for late-stage derivatization of biologically active compounds via the boronate esters. The unique capabilities of this method are demonstrated by combining carbon-boron bond-forming reactions with palladium-catalyzed methylation in a tandem transformation.Organic lettersPalladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters.PMC6827334R01 GM115812R35 GM130387Hartwig JFHaydl AM48falsePalladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters.A method for the direct methylation of aryl, heteroaryl, and vinyl boronate esters is reported, involving the reaction of iodomethane with aryl-, heteroaryl-, and vinylboronate esters catalyzed by palladium and PtBu2Me. This transformation occurs with a remarkably broad scope and is suitable for late-stage derivatization of biologically active compounds via the boronate esters. The unique capabilities of this method are demonstrated by combining carbon-boron bond-forming reactions with palladium-catalyzed methylation in a tandem transformation.2019-01-01T00:00:00Z2019 Mar2020-10-29T10:23:28Z2019-11-12T08:07:04ZS-EPMC68273343076310910.1021/acs.orglett.9b00025