{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu Y"],"funding":["the Natural Science Foundation of Beijing Municipality","the China National Funds for Distinguished Young Scientists"],"pagination":["268"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6829840"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["BACKGROUND:Secondary central nervous system lymphoma (SCNSL) is defined as secondary central nervous system (CNS) involvement in patients with systemic lymphoma. It is considered a profoundly adverse complication with inferior clinical outcome. Parenchymal involvement in the CNS in aggressive B-cell lymphoma is not frequently seen and remains a diagnostic dilemma. METHODS:In our study, we retrospectively analyzed the clinical and magnetic resonance imaging (MRI) features of 26 parenchymal SCNSL patients. In addition, we compared MRI features of SCNSL and primary CNS lymphoma (PCNSL) patients after 1:1 propensity score matching. Also we presented two SCNSL cases with atypical MRI appearance. RESULTS:Among SCNSL patients, the median CNS relapse time was 3 months, and multiple lesions were fo"],"journal":["BMC neurology"],"pubmed_title":["Parenchymal central nervous system involvement in aggressive B-cell lymphoma: retrospective analysis of clinical and MRI features in a Chinese population."],"pmcid":["PMC6829840"],"funding_grant_id":["7172071","81500157"],"pubmed_authors":["Qian J","Liu Q","Zhu H","Sun X","Bai X","Cui Q","Ji N","Liu Y","Guo J","Sun S","Xing R","Chen Y","Wang Y","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Parenchymal central nervous system involvement in aggressive B-cell lymphoma: retrospective analysis of clinical and MRI features in a Chinese population.","description":"BACKGROUND:Secondary central nervous system lymphoma (SCNSL) is defined as secondary central nervous system (CNS) involvement in patients with systemic lymphoma. It is considered a profoundly adverse complication with inferior clinical outcome. Parenchymal involvement in the CNS in aggressive B-cell lymphoma is not frequently seen and remains a diagnostic dilemma. METHODS:In our study, we retrospectively analyzed the clinical and magnetic resonance imaging (MRI) features of 26 parenchymal SCNSL patients. In addition, we compared MRI features of SCNSL and primary CNS lymphoma (PCNSL) patients after 1:1 propensity score matching. Also we presented two SCNSL cases with atypical MRI appearance. RESULTS:Among SCNSL patients, the median CNS relapse time was 3 months, and multiple lesions were fo","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2025-04-20T00:26:32.45Z","creation":"2019-11-15T08:05:30Z"},"accession":"S-EPMC6829840","cross_references":{"pubmed":["31684888"],"doi":["10.1186/s12883-019-1511-3"]}}