biostudies-literatureUnknown18(1)Markus MRPBACKGROUND:Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes. METHODS:Cross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent poCardiovascular diabetology145https://www.ebi.ac.uk/biostudies/studies/S-EPMC6829934biostudies-literatureGlucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart.PMC6829934Rathmann WLorbeer RPeters AFelix SBDorr MSchipf SVolzke HSiewert-Markus UMarkus MRPMeisinger CPtushkina VStorz CBahls MBamberg FRospleszcz SIttermann TBaumeister SEBulow RNauck MfalseGlucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart.BACKGROUND:Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes. METHODS:Cross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent po2019-01-01T00:00:00Z2019 Nov2025-04-19T21:55:59.762Z2019-11-15T08:05:31ZS-EPMC68299343168494510.1186/s12933-019-0948-4