{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(20)"],"submitter":["Chen J"],"pubmed_abstract":["Non-alcoholic fatty liver disease (NAFLD) can progress from steatosis to non-alcoholic steatohepatitis (NASH) characterized by liver inflammation, possibly leading to cirrhosis and hepatocellular carcinoma (HCC). Mice with impaired macrophage activation, when fed a high-fat diet, develop severe NASH. Evidence is mounting that Kupffer cells are implicated. However, it is unknown whether the resident CD68+ or bone marrow-derived CD11b+ Kupffer cells are involved. Characterization of the FSP1cre-Pparb/d-/- mouse liver revealed that FSP1 is expressed in CD11b+ Kupffer cells. Although these cells only constitute a minute fraction of the liver cell population, Pparb/d deletion in these cells led to remarkable hepatic phenotypic changes. We report that a higher lipid content was present in postna"],"journal":["International journal of molecular sciences"],"pagination":["E5115"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6830345"],"repository":["biostudies-literature"],"pubmed_title":["The Potential of the FSP1cre-Pparb/d-/- Mouse Model for Studying Juvenile NAFLD."],"pmcid":["PMC6830345"],"pubmed_authors":["Wahli W","Tan NS","Chen J","Sng MK","Zhuang Y"],"additional_accession":[]},"is_claimable":false,"name":"The Potential of the FSP1cre-Pparb/d-/- Mouse Model for Studying Juvenile NAFLD.","description":"Non-alcoholic fatty liver disease (NAFLD) can progress from steatosis to non-alcoholic steatohepatitis (NASH) characterized by liver inflammation, possibly leading to cirrhosis and hepatocellular carcinoma (HCC). Mice with impaired macrophage activation, when fed a high-fat diet, develop severe NASH. Evidence is mounting that Kupffer cells are implicated. However, it is unknown whether the resident CD68+ or bone marrow-derived CD11b+ Kupffer cells are involved. Characterization of the FSP1cre-Pparb/d-/- mouse liver revealed that FSP1 is expressed in CD11b+ Kupffer cells. Although these cells only constitute a minute fraction of the liver cell population, Pparb/d deletion in these cells led to remarkable hepatic phenotypic changes. We report that a higher lipid content was present in postna","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2025-04-18T17:13:53.572Z","creation":"2020-05-21T19:03:42Z"},"accession":"S-EPMC6830345","cross_references":{"pubmed":["31618976"],"doi":["10.3390/ijms20205115"]}}