biostudies-literatureGuerville FPierre Fabre Research InstituteINSERMUniversity Hospital Center of ToulouseUniversity of Toulouse IIIFrench Ministry of HealthAvid Radiopharmaceuticals1597-1604https://www.ebi.ac.uk/biostudies/studies/S-EPMC6832058biostudies-literatureUnknown14(11)BACKGROUND AND OBJECTIVES:Low eGFR is known to be associated with frailty, but the association between the longitudinal decline of eGFR and incident frailty in older persons remains to be determined. The objective of this study was to investigate whether a fast decline on eGFR would be associated with incident frailty. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:Community dwellers, aged ≥70, were included in this secondary analysis of the 5-year Multidomain Alzheimer Preventive Trial (MAPT). eGFR was calculated using CKD-Epidemiology Collaboration equation at baseline and at 6, 12, and 24 months. The lowest quartile of eGFR slope (-4.1 ml/min per 1.73 m2 per yr) defined a fast decline. The frailty phenotype (unintentional weight loss, exhaustion, low physical activity, slow gait, low hanClinical journal of the American Society of Nephrology : CJASNEstimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults.PMC6832058PHRC 2008, 2009Taton BVellas BRolland YMultidomain Alzheimer Preventive Trial (MAPT)/Data Sharing Alzheimer (DSA) Groupde Souto Barreto PGuerville FBourdel-Marchasson IfalseEstimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults.BACKGROUND AND OBJECTIVES:Low eGFR is known to be associated with frailty, but the association between the longitudinal decline of eGFR and incident frailty in older persons remains to be determined. The objective of this study was to investigate whether a fast decline on eGFR would be associated with incident frailty. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:Community dwellers, aged ≥70, were included in this secondary analysis of the 5-year Multidomain Alzheimer Preventive Trial (MAPT). eGFR was calculated using CKD-Epidemiology Collaboration equation at baseline and at 6, 12, and 24 months. The lowest quartile of eGFR slope (-4.1 ml/min per 1.73 m2 per yr) defined a fast decline. The frailty phenotype (unintentional weight loss, exhaustion, low physical activity, slow gait, low han2019-01-01T00:00:00Z2019 Nov2025-04-04T14:59:09.095Z2025-04-04T14:59:09.095ZS-EPMC68320583162811810.2215/CJN.0375031910.2215/cjn.03750319