{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yamamura H"],"funding":["Japan Society for the Promotion of Science"],"pagination":["1432-1437"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6836745"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(8)"],"pubmed_abstract":["A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di-<i>O</i>-propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells."],"journal":["MedChemComm"],"pubmed_title":["Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes."],"pmcid":["PMC6836745"],"funding_grant_id":["15K07857"],"pubmed_authors":["Kato H","Yamamura H","Katsu T","Isshiki K","Osawa K","Masuda K","Miyagawa A","Fujita Y"],"additional_accession":[]},"is_claimable":false,"name":"Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes.","description":"A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di-<i>O</i>-propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-04T23:22:09.931Z","creation":"2025-04-04T23:22:09.931Z"},"accession":"S-EPMC6836745","cross_references":{"pubmed":["31803397"],"doi":["10.1039/c9md00229d"]}}