biostudies-literatureYamamura HJapan Society for the Promotion of Science1432-1437https://www.ebi.ac.uk/biostudies/studies/S-EPMC6836745biostudies-literatureUnknown10(8)A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di-<i>O</i>-propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells.MedChemCommGramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes.PMC683674515K07857Kato HYamamura HKatsu TIsshiki KOsawa KMasuda KMiyagawa AFujita YfalseGramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes.A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di-<i>O</i>-propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells.2019-01-01T00:00:00Z2019 Aug2025-04-04T23:22:09.931Z2025-04-04T23:22:09.931ZS-EPMC68367453180339710.1039/c9md00229d