{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun GL"],"funding":["NIEHS NIH HHS","Bose Research Grant, MIT","U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences"],"pagination":["5080"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6841955"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Hyperaccumulators typically refer to plants that absorb and tolerate elevated amounts of heavy metals. Due to their unique metal trafficking abilities, hyperaccumulators are promising candidates for bioremediation applications. However, compared to bacteria-based bioremediation systems, plant life cycle is long and growing conditions are difficult to maintain hindering their adoption. Herein, we combine the robust growth and engineerability of bacteria with the unique waste management mechanisms of plants by using a more tractable platform-the common baker's yeast-to create plant-like hyperaccumulators. Through overexpression of metal transporters and engineering metal trafficking pathways, engineered yeast strains are able to sequester metals at concentrations 10-100 times more than estab"],"journal":["Nature communications"],"pubmed_title":["Designing yeast as plant-like hyperaccumulators for heavy metals."],"pmcid":["PMC6841955"],"funding_grant_id":["P30 ES002109","P30-ES002109"],"pubmed_authors":["Belcher AM","Reynolds EE","Sun GL"],"additional_accession":[]},"is_claimable":false,"name":"Designing yeast as plant-like hyperaccumulators for heavy metals.","description":"Hyperaccumulators typically refer to plants that absorb and tolerate elevated amounts of heavy metals. Due to their unique metal trafficking abilities, hyperaccumulators are promising candidates for bioremediation applications. However, compared to bacteria-based bioremediation systems, plant life cycle is long and growing conditions are difficult to maintain hindering their adoption. Herein, we combine the robust growth and engineerability of bacteria with the unique waste management mechanisms of plants by using a more tractable platform-the common baker's yeast-to create plant-like hyperaccumulators. Through overexpression of metal transporters and engineering metal trafficking pathways, engineered yeast strains are able to sequester metals at concentrations 10-100 times more than estab","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2026-05-03T20:59:20.812Z","creation":"2025-05-18T12:58:08.085Z"},"accession":"S-EPMC6841955","cross_references":{"pubmed":["31704944"],"doi":["10.1038/s41467-019-13093-6"]}}