{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["59(4)"],"submitter":["Sujitha S"],"pubmed_abstract":["The proportion of people suffering from cardiovascular diseases has risen by 34% in the last 15 years in India. Cardiomyopathy is among the many forms of CVD s present. Infection of heart muscles is the suspected etiological agent for the same. Oral pathogens gaining entry into the bloodstream are responsible for such infections. <i>Streptococcus mutans</i> is an oral pathogen with implications in cardiovascular diseases. Previous studies have shown certain strains of <i>S. mutans</i> are found predominantly within atherosclerotic plaques and extirpated valves. To decipher the genetic differences responsible for endothelial cell invasion, we have sequenced the genome of <i>Streptococcus mutans</i> B14. Pan-genome analysis, search for adhesion proteins through a special algorithm, and protein-protein interactions search through HPIDB have been done. Pan-genome analysis of 187 whole genomes, assemblies revealed 6965 genes in total and 918 genes forming the core gene cluster. Adhesion to the endothelial cell is a critical virulence factor distinguishing virulent and non-virulent strains. Overall, 4% of the total proteins in <i>S. mutans</i> B14 were categorized as adhesion proteins. Protein-protein interaction between putative adhesion proteins and Human extracellular matrix components was predicted, revealing novel interactions. A conserved gene catalyzing the synthesis of branched-chain amino acids in <i>S. mutans</i> B14 shows possible interaction with isoforms of cathepsin protein of the ECM. This genome sequence analysis indicates towards other proteins in the <i>S. mutans</i> genome, which might have a specific role to play in host cell interaction."],"journal":["Indian journal of microbiology"],"pagination":["451-459"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6842392"],"repository":["biostudies-literature"],"pubmed_title":["Genome Investigation of a Cariogenic Pathogen with Implications in Cardiovascular Diseases."],"pmcid":["PMC6842392"],"pubmed_authors":["Sujitha S","Karthikeyan R","Rajendhran J","Sankarasubramanian J","Vishnu US","Gunasekaran P"],"additional_accession":[]},"is_claimable":false,"name":"Genome Investigation of a Cariogenic Pathogen with Implications in Cardiovascular Diseases.","description":"The proportion of people suffering from cardiovascular diseases has risen by 34% in the last 15 years in India. Cardiomyopathy is among the many forms of CVD s present. Infection of heart muscles is the suspected etiological agent for the same. Oral pathogens gaining entry into the bloodstream are responsible for such infections. <i>Streptococcus mutans</i> is an oral pathogen with implications in cardiovascular diseases. Previous studies have shown certain strains of <i>S. mutans</i> are found predominantly within atherosclerotic plaques and extirpated valves. To decipher the genetic differences responsible for endothelial cell invasion, we have sequenced the genome of <i>Streptococcus mutans</i> B14. Pan-genome analysis, search for adhesion proteins through a special algorithm, and protein-protein interactions search through HPIDB have been done. Pan-genome analysis of 187 whole genomes, assemblies revealed 6965 genes in total and 918 genes forming the core gene cluster. Adhesion to the endothelial cell is a critical virulence factor distinguishing virulent and non-virulent strains. Overall, 4% of the total proteins in <i>S. mutans</i> B14 were categorized as adhesion proteins. Protein-protein interaction between putative adhesion proteins and Human extracellular matrix components was predicted, revealing novel interactions. A conserved gene catalyzing the synthesis of branched-chain amino acids in <i>S. mutans</i> B14 shows possible interaction with isoforms of cathepsin protein of the ECM. This genome sequence analysis indicates towards other proteins in the <i>S. mutans</i> genome, which might have a specific role to play in host cell interaction.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2026-05-03T20:31:31.556Z","creation":"2021-02-20T02:48:13Z"},"accession":"S-EPMC6842392","cross_references":{"pubmed":["31762508"],"doi":["10.1007/s12088-019-00823-z"]}}