{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao LX"],"funding":["the &amp;quot;Academic Backbone&amp;quot; Project of Northeast Agricultural University","the Research Science Foundation in Technology Innovation of Harbin","Natural Science Foundation of Heilongjiang Province of China","National Natural Science Foundation of China"],"pagination":["E514"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6843476"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(10)"],"pubmed_abstract":["The herbicide fomesafen has the advantages of low toxicity and high selectivity, and the target of this compound is protoporphyrinogen IX oxidase (PPO, EC 1.3.3.4). However, this herbicide has a long residual period and can have phytotoxic effects on succeeding crops. To protect maize from fomesafen, a series of thiazole phenoxypyridines were designed based on structure-activity relationships, active substructure combinations, and bioisosterism. Bioassays showed that thiazole phenoxypyridines could improve maize tolerance under fomesafen toxicity stress to varying degrees at a dose of 10 mg·kg<sup>-1</sup>. Compound <b>4i</b> exhibited the best effects. After being treated by compound <b>4i</b>, average recovery rates of growth index exceeded 72%, glutathione content markedly increased by "],"journal":["Biomolecules"],"pubmed_title":["Novel Thiazole Phenoxypyridine Derivatives Protect Maize from Residual Pesticide Injury Caused by PPO-Inhibitor Fomesafen."],"pmcid":["PMC6843476"],"funding_grant_id":["31572042","2017RAQXJ017","16XG24","ZD2017002"],"pubmed_authors":["Zhao LX","Zou YL","Yin ML","Fu Y","Ye F","Ren T","Gao S","Wang QR"],"additional_accession":[]},"is_claimable":false,"name":"Novel Thiazole Phenoxypyridine Derivatives Protect Maize from Residual Pesticide Injury Caused by PPO-Inhibitor Fomesafen.","description":"The herbicide fomesafen has the advantages of low toxicity and high selectivity, and the target of this compound is protoporphyrinogen IX oxidase (PPO, EC 1.3.3.4). However, this herbicide has a long residual period and can have phytotoxic effects on succeeding crops. To protect maize from fomesafen, a series of thiazole phenoxypyridines were designed based on structure-activity relationships, active substructure combinations, and bioisosterism. Bioassays showed that thiazole phenoxypyridines could improve maize tolerance under fomesafen toxicity stress to varying degrees at a dose of 10 mg·kg<sup>-1</sup>. Compound <b>4i</b> exhibited the best effects. After being treated by compound <b>4i</b>, average recovery rates of growth index exceeded 72%, glutathione content markedly increased by ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2026-04-08T00:27:59.206Z","creation":"2020-05-21T20:01:35Z"},"accession":"S-EPMC6843476","cross_references":{"pubmed":["31547161"],"doi":["10.3390/biom9100514"]}}