biostudies-literatureZhao LXthe &quot;Academic Backbone&quot; Project of Northeast Agricultural Universitythe Research Science Foundation in Technology Innovation of HarbinNatural Science Foundation of Heilongjiang Province of ChinaNational Natural Science Foundation of ChinaE514https://www.ebi.ac.uk/biostudies/studies/S-EPMC6843476biostudies-literatureUnknown9(10)The herbicide fomesafen has the advantages of low toxicity and high selectivity, and the target of this compound is protoporphyrinogen IX oxidase (PPO, EC 1.3.3.4). However, this herbicide has a long residual period and can have phytotoxic effects on succeeding crops. To protect maize from fomesafen, a series of thiazole phenoxypyridines were designed based on structure-activity relationships, active substructure combinations, and bioisosterism. Bioassays showed that thiazole phenoxypyridines could improve maize tolerance under fomesafen toxicity stress to varying degrees at a dose of 10 mg·kg-1. Compound 4i exhibited the best effects. After being treated by compound 4i, average recovery rates of growth index exceeded 72%, glutathione content markedly increased by BiomoleculesNovel Thiazole Phenoxypyridine Derivatives Protect Maize from Residual Pesticide Injury Caused by PPO-Inhibitor Fomesafen.PMC6843476315720422017RAQXJ01716XG24ZD2017002Zhao LXZou YLYin MLFu YYe FRen TGao SWang QRfalseNovel Thiazole Phenoxypyridine Derivatives Protect Maize from Residual Pesticide Injury Caused by PPO-Inhibitor Fomesafen.The herbicide fomesafen has the advantages of low toxicity and high selectivity, and the target of this compound is protoporphyrinogen IX oxidase (PPO, EC 1.3.3.4). However, this herbicide has a long residual period and can have phytotoxic effects on succeeding crops. To protect maize from fomesafen, a series of thiazole phenoxypyridines were designed based on structure-activity relationships, active substructure combinations, and bioisosterism. Bioassays showed that thiazole phenoxypyridines could improve maize tolerance under fomesafen toxicity stress to varying degrees at a dose of 10 mg·kg-1. Compound 4i exhibited the best effects. After being treated by compound 4i, average recovery rates of growth index exceeded 72%, glutathione content markedly increased by 2019-01-01T00:00:00Z2019 Sep2026-04-08T00:27:59.206Z2020-05-21T20:01:35ZS-EPMC68434763154716110.3390/biom9100514