{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(19)"],"submitter":["Barmak A"],"funding":["Research Council, Persian Gulf University"],"pubmed_abstract":["A series of new quinazoline derivatives were designed and synthesized via a one-pot condensation reaction between isatoic anhydride and aromatic aldehydes with anilines using aluminum sulfate as a catalyst in refluxing ethanol. Their structures were confirmed by their physical, IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and mass spectroscopy data and evaluated for some biological effects, including the antioxidant and α-glucosidase inhibitory activities as well as some in vivo hematological parameters. The ability of synthesized compounds in the inhibition of α-glucosidase was also investigated through the in silico study. The significant and important changes in some hematological tests were perceived. Notably, compound <b>4h</b> showed more reducing effects on cholesterol and triglycerid"],"journal":["ACS omega"],"pagination":["18087-18099"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6843711"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis, Structural Studies, and α-Glucosidase Inhibitory, Antidiabetic, and Antioxidant Activities of 2,3-Dihydroquinazolin-4(1<i>H</i>)-ones Derived from Pyrazol-4-carbaldehyde and Anilines."],"pmcid":["PMC6843711"],"pubmed_authors":["Barmak A","Niknam K","Mohebbi G"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis, Structural Studies, and α-Glucosidase Inhibitory, Antidiabetic, and Antioxidant Activities of 2,3-Dihydroquinazolin-4(1<i>H</i>)-ones Derived from Pyrazol-4-carbaldehyde and Anilines.","description":"A series of new quinazoline derivatives were designed and synthesized via a one-pot condensation reaction between isatoic anhydride and aromatic aldehydes with anilines using aluminum sulfate as a catalyst in refluxing ethanol. Their structures were confirmed by their physical, IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and mass spectroscopy data and evaluated for some biological effects, including the antioxidant and α-glucosidase inhibitory activities as well as some in vivo hematological parameters. The ability of synthesized compounds in the inhibition of α-glucosidase was also investigated through the in silico study. The significant and important changes in some hematological tests were perceived. Notably, compound <b>4h</b> showed more reducing effects on cholesterol and triglycerid","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2025-04-21T20:38:45.263Z","creation":"2020-05-21T18:35:45Z"},"accession":"S-EPMC6843711","cross_references":{"pubmed":["31720511"],"doi":["10.1021/acsomega.9b01906"]}}