biostudies-literatureUnknown4(19)Barmak AResearch Council, Persian Gulf UniversityA series of new quinazoline derivatives were designed and synthesized via a one-pot condensation reaction between isatoic anhydride and aromatic aldehydes with anilines using aluminum sulfate as a catalyst in refluxing ethanol. Their structures were confirmed by their physical, IR, ¹H NMR, ¹³C NMR, and mass spectroscopy data and evaluated for some biological effects, including the antioxidant and α-glucosidase inhibitory activities as well as some in vivo hematological parameters. The ability of synthesized compounds in the inhibition of α-glucosidase was also investigated through the in silico study. The significant and important changes in some hematological tests were perceived. Notably, compound <b>4h</b> showed more reducing effects on cholesterol and triglyceridACS omega18087-18099https://www.ebi.ac.uk/biostudies/studies/S-EPMC6843711biostudies-literatureSynthesis, Structural Studies, and α-Glucosidase Inhibitory, Antidiabetic, and Antioxidant Activities of 2,3-Dihydroquinazolin-4(1<i>H</i>)-ones Derived from Pyrazol-4-carbaldehyde and Anilines.PMC6843711Barmak ANiknam KMohebbi GfalseSynthesis, Structural Studies, and α-Glucosidase Inhibitory, Antidiabetic, and Antioxidant Activities of 2,3-Dihydroquinazolin-4(1<i>H</i>)-ones Derived from Pyrazol-4-carbaldehyde and Anilines.A series of new quinazoline derivatives were designed and synthesized via a one-pot condensation reaction between isatoic anhydride and aromatic aldehydes with anilines using aluminum sulfate as a catalyst in refluxing ethanol. Their structures were confirmed by their physical, IR, ¹H NMR, ¹³C NMR, and mass spectroscopy data and evaluated for some biological effects, including the antioxidant and α-glucosidase inhibitory activities as well as some in vivo hematological parameters. The ability of synthesized compounds in the inhibition of α-glucosidase was also investigated through the in silico study. The significant and important changes in some hematological tests were perceived. Notably, compound <b>4h</b> showed more reducing effects on cholesterol and triglycerid2019-01-01T00:00:00Z2019 Nov2025-04-21T20:38:45.263Z2020-05-21T18:35:45ZS-EPMC68437113172051110.1021/acsomega.9b01906