{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chao XJ"],"funding":["Fundamental Research Funds for the Central Universities","NSF China","Basic Frontier Scientific Research Program","Strategic Priority Research Program of CAS","NIH"],"pagination":["10520-10528"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6847114"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["47(20)"],"pubmed_abstract":["We have found recently that nuclear uptake of the cell-impermeable DNA light-switching Ru(II)-polypyridyl cationic complexes such as [Ru(bpy)2(dppz)]Cl2 was remarkably enhanced by pentachlorophenol (PCP), by forming ion-pairing complexes via a passive diffusion mechanism. However, it is not clear whether the enhanced nuclear uptake of [Ru(bpy)2(dppz)]2+ is only limited to PCP, or it is a general phenomenon for other highly chlorinated phenols (HCPs); and if so, what are the major physicochemical factors in determining nuclear uptake? Here, we found that the nuclear uptake of [Ru(bpy)2(dppz)]2+ can also be facilitated by other two groups of HCPs including three tetrachlorophenol (TeCP) and six trichlorophenol (TCP) isomers. Interestingly and unexpectedly, 2,3,4,5-TeCP was found to be the mo"],"journal":["Nucleic acids research"],"pubmed_title":["Targeted live-cell nuclear delivery of the DNA 'light-switching' Ru(II) complex via ion-pairing with chlorophenolate counter-anions: the critical role of binding stability and lipophilicity of the ion-pairing complexes."],"pmcid":["PMC6847114"],"funding_grant_id":["ES00210","21477139","RR01008","21621064","XDB01020300","ZDBS-LY-SLH027","2018A030310242","21407163","21777180","18zxxxt38","21836005","ES11497","21577149"],"pubmed_authors":["Yan ZY","Tang M","Zhu BZ","Shao J","Huang CH","Chao XJ","Huang R"],"additional_accession":[]},"is_claimable":false,"name":"Targeted live-cell nuclear delivery of the DNA 'light-switching' Ru(II) complex via ion-pairing with chlorophenolate counter-anions: the critical role of binding stability and lipophilicity of the ion-pairing complexes.","description":"We have found recently that nuclear uptake of the cell-impermeable DNA light-switching Ru(II)-polypyridyl cationic complexes such as [Ru(bpy)2(dppz)]Cl2 was remarkably enhanced by pentachlorophenol (PCP), by forming ion-pairing complexes via a passive diffusion mechanism. However, it is not clear whether the enhanced nuclear uptake of [Ru(bpy)2(dppz)]2+ is only limited to PCP, or it is a general phenomenon for other highly chlorinated phenols (HCPs); and if so, what are the major physicochemical factors in determining nuclear uptake? Here, we found that the nuclear uptake of [Ru(bpy)2(dppz)]2+ can also be facilitated by other two groups of HCPs including three tetrachlorophenol (TeCP) and six trichlorophenol (TCP) isomers. Interestingly and unexpectedly, 2,3,4,5-TeCP was found to be the mo","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2025-04-04T12:17:58.418Z","creation":"2020-05-21T19:06:04Z"},"accession":"S-EPMC6847114","cross_references":{"pubmed":["31584083"],"doi":["10.1093/nar/gkz152"]}}