biostudies-literatureUnknown7(11)Dinel AL<i>Rhodiola rosea</i> L. (<i>R. rosea</i>) is an adaptogenic plant increasing body resistance to stress. Its efficacy has been evidenced mainly in chronic stress models, data concerning its effect in acute stress and underlying mechanisms being scarce. The objective was to investigate the effect of repeated doses of a <i>R. rosea</i> hydroethanolic root extract (HRE) on hypothalamic pituitary adrenal response in a murine model of acute mild stress and also the mechanisms involved. Stress response was measured in Balb/c mice having received by gavage HRE (5 g/kg) or vehicle daily for 2 weeks before being submitted to an acute mild stress protocol (open-field test then elevated plus maze). Corticosterone was measured in plasma from mandibular vein blood drawn before and 30, 60, and 90 min afFood science & nutrition3827-3841https://www.ebi.ac.uk/biostudies/studies/S-EPMC6848809biostudies-literatureReduction of acute mild stress corticosterone response and changes in stress-responsive gene expression in male Balb/c mice after repeated administration of a <i>Rhodiola rosea</i> L. root extract.PMC6848809Joffre CPallet VBerthomier LBardot VLaye SRipoche IGuinobert ILucas CBlondeau CDinel ALfalseReduction of acute mild stress corticosterone response and changes in stress-responsive gene expression in male Balb/c mice after repeated administration of a <i>Rhodiola rosea</i> L. root extract.<i>Rhodiola rosea</i> L. (<i>R. rosea</i>) is an adaptogenic plant increasing body resistance to stress. Its efficacy has been evidenced mainly in chronic stress models, data concerning its effect in acute stress and underlying mechanisms being scarce. The objective was to investigate the effect of repeated doses of a <i>R. rosea</i> hydroethanolic root extract (HRE) on hypothalamic pituitary adrenal response in a murine model of acute mild stress and also the mechanisms involved. Stress response was measured in Balb/c mice having received by gavage HRE (5 g/kg) or vehicle daily for 2 weeks before being submitted to an acute mild stress protocol (open-field test then elevated plus maze). Corticosterone was measured in plasma from mandibular vein blood drawn before and 30, 60, and 90 min af2019-01-01T00:00:00Z2019 Nov2025-04-26T01:49:13.262Z2020-05-21T19:41:35ZS-EPMC68488093176303210.1002/fsn3.1249