{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ahyong V"],"funding":["HHS | National Institutes of Health","NCRR NIH HHS","NIAID NIH HHS","NCI NIH HHS"],"pagination":["e00536-19"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6854040"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(6)"],"pubmed_abstract":["Gram-negative bacteria in the order <i>Rickettsiales</i> have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever. The bacteria have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome reduction. However, it remains largely unknown which nutrients they acquire and whether their metabolic dependency can be exploited therapeutically. Here, we describe a genetic rewiring of bacterial isoprenoid biosynthetic pathways in the <i>Rickettsiales</i> that has resulted from reductive genome evolution. Furthermore, we investigated whether the spotted fever group <i>Rickettsia</i> species <i>Rickettsia parkeri</i> scavenges isoprenoid precursors directly from the host. Using "],"journal":["mSphere"],"pubmed_title":["A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics."],"pmcid":["PMC6854040"],"funding_grant_id":["R01 CA172667","R21 AI109270","S10 RR027696","F32 AI133912","R01 AI109044"],"pubmed_authors":["Ahyong V","Burke TP","Nomura DK","Berdan CA","Welch MD"],"additional_accession":[]},"is_claimable":false,"name":"A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics.","description":"Gram-negative bacteria in the order <i>Rickettsiales</i> have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever. The bacteria have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome reduction. However, it remains largely unknown which nutrients they acquire and whether their metabolic dependency can be exploited therapeutically. Here, we describe a genetic rewiring of bacterial isoprenoid biosynthetic pathways in the <i>Rickettsiales</i> that has resulted from reductive genome evolution. Furthermore, we investigated whether the spotted fever group <i>Rickettsia</i> species <i>Rickettsia parkeri</i> scavenges isoprenoid precursors directly from the host. Using ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2026-06-17T06:54:58.853Z","creation":"2020-05-22T10:49:07Z"},"accession":"S-EPMC6854040","cross_references":{"pubmed":["31722991"],"doi":["10.1128/mSphere.00536-19"]}}