{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Jin T"],"pubmed_abstract":["Septic arthritis is one of the most aggressive joint diseases. Although caused predominantly by S. aureus, Gram-negative bacteria, Pseudomonas aeruginosa among them, account for a significant percentage of the causal agents of septic arthritis. However, septic arthritis caused by P. aeruginosa has not been studied thus far, due to lack of an animal model. NMRI mice were inoculated with different doses of P. aeruginosa. The clinical course of septic arthritis and radiological changes of joints were examined. Furthermore, the host molecular and cellular mechanisms involved in P. aeruginosa-induced septic arthritis were investigated. Inoculation of mice with P. aeruginosa caused septic arthritis in a dose-dependent manner. Neutrophil depletion led to higher mortality and more severe joint des"],"journal":["Scientific reports"],"pagination":["16868"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6856550"],"repository":["biostudies-literature"],"pubmed_title":["A novel mouse model for septic arthritis induced by Pseudomonas aeruginosa."],"pmcid":["PMC6856550"],"pubmed_authors":["Hu Z","Jin T","Moore ERB","Ali A","Fei Y","Pullerits R","Mohammad M"],"additional_accession":[]},"is_claimable":false,"name":"A novel mouse model for septic arthritis induced by Pseudomonas aeruginosa.","description":"Septic arthritis is one of the most aggressive joint diseases. Although caused predominantly by S. aureus, Gram-negative bacteria, Pseudomonas aeruginosa among them, account for a significant percentage of the causal agents of septic arthritis. However, septic arthritis caused by P. aeruginosa has not been studied thus far, due to lack of an animal model. NMRI mice were inoculated with different doses of P. aeruginosa. The clinical course of septic arthritis and radiological changes of joints were examined. Furthermore, the host molecular and cellular mechanisms involved in P. aeruginosa-induced septic arthritis were investigated. Inoculation of mice with P. aeruginosa caused septic arthritis in a dose-dependent manner. Neutrophil depletion led to higher mortality and more severe joint des","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2025-04-25T18:37:22.695Z","creation":"2020-05-21T23:30:13Z"},"accession":"S-EPMC6856550","cross_references":{"pubmed":["31727989"],"doi":["10.1038/s41598-019-53434-5"]}}