{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen TH"],"funding":["Ministry of Science and Technology, Taiwan","Kaohsiung Medical University Hospital"],"pagination":["E4079"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6862333"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(21)"],"pubmed_abstract":["Health of the metal industrial workers should be a noteworthy issue due to the hazard ofchronic exposure to metals or toxic elements. The interactions among multiple elements aresophisticated and may differ from person to person. Tumor necrosis factor-α (TNF-α) genepolymorphisms were supposed to be involved with the interactions because TNF-α plays animportant role in inflammation, a mechanism by which toxic elements cause threats to humanhealth. This research aimed to analyze the influence of TNF-αgene polymorphisms and multielementson serum TNF-α level. Blood multi-elements concentrations (lead, cadmium, arsenic,selenium, cobalt, copper, and zinc), serum TNF-α level, and TNF-α single nucleotidepolymorphisms (SNPs), including -238G > A (rs361525), -308G > A (rs1800629), -857C > T(rs1799724), -863C > A (rs1800630), and -1031T > C (rs1799964), were measured in 462 metalindustrial workers. We applied mixed-effect models to analyze the interactions among multielementsand TNF-α SNPs. Blood concentration of all elements were positively associated withserum TNF-α level, and the effects may be modified by TNF-α gene polymorphisms. Our studyrevealed that TNF-α -308A/A and -1031C/C may be susceptible genotypes, and thus we suggestthat those workers should take preventive measures against metal toxicity."],"journal":["International journal of environmental research and public health"],"pubmed_title":["The Association of Serum TNF-α Levels and Blood Multi-Elements Modified by TNF-α Gene Polymorphisms in Metal Industrial Workers."],"pmcid":["PMC6862333"],"funding_grant_id":["MOST 105-2314-B-037-018-MY3","KMUH107-7R85"],"pubmed_authors":["Sun HY","Huang JJ","Chuang HY","Lee SS","Chen TH","Kung WS"],"additional_accession":[]},"is_claimable":false,"name":"The Association of Serum TNF-α Levels and Blood Multi-Elements Modified by TNF-α Gene Polymorphisms in Metal Industrial Workers.","description":"Health of the metal industrial workers should be a noteworthy issue due to the hazard ofchronic exposure to metals or toxic elements. The interactions among multiple elements aresophisticated and may differ from person to person. Tumor necrosis factor-α (TNF-α) genepolymorphisms were supposed to be involved with the interactions because TNF-α plays animportant role in inflammation, a mechanism by which toxic elements cause threats to humanhealth. This research aimed to analyze the influence of TNF-αgene polymorphisms and multielementson serum TNF-α level. Blood multi-elements concentrations (lead, cadmium, arsenic,selenium, cobalt, copper, and zinc), serum TNF-α level, and TNF-α single nucleotidepolymorphisms (SNPs), including -238G > A (rs361525), -308G > A (rs1800629), -857C > T(rs1799724), -863C > A (rs1800630), and -1031T > C (rs1799964), were measured in 462 metalindustrial workers. We applied mixed-effect models to analyze the interactions among multielementsand TNF-α SNPs. Blood concentration of all elements were positively associated withserum TNF-α level, and the effects may be modified by TNF-α gene polymorphisms. Our studyrevealed that TNF-α -308A/A and -1031C/C may be susceptible genotypes, and thus we suggestthat those workers should take preventive measures against metal toxicity.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2024-11-19T15:27:29.296Z","creation":"2020-05-21T21:09:12Z"},"accession":"S-EPMC6862333","cross_references":{"pubmed":["31652851"],"doi":["10.3390/ijerph16214079"]}}