{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hammad SM"],"funding":["NCATS NIH HHS","NCRR NIH HHS","NHLBI NIH HHS","NCI NIH HHS","National Institutes of Health","NIAMS NIH HHS","NIGMS NIH HHS"],"pagination":["e0224496"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6867606"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(11)"],"pubmed_abstract":["Systemic lupus erythematous (SLE) is a chronic multi-organ autoimmune disease. Genetic and environmental factors contribute to disease onset and severity. Sphingolipids are signaling molecules involved in regulating cell functions and have been associated with multiple genetic disease processes. African-Americans are more likely to suffer from SLE morbidity than Whites. The Medical University of South Carolina has banked plasma samples from a well-characterized lupus cohort that includes African-Americans and Whites. This study examined the influence of race on plasma sphingolipid profiles in SLE patients and association of sphingolipid levels with comorbid atherosclerosis and SLE disease activity. Mass spectrometry revealed that healthy African-Americans had higher sphingomyelin levels an"],"journal":["PloS one"],"pubmed_title":["Race disparity in blood sphingolipidomics associated with lupus cardiovascular comorbidity."],"pmcid":["PMC6867606"],"funding_grant_id":["P30 AR072582","P30 CA138313","UL1 TR001450","K23 AR052364","R25 HL092611","UL1 RR025741","M01 RR001070","P60 AR062755","R25 HL092611-11","P30 GM103339"],"pubmed_authors":["Hammad SM","Oates JC","Nietert PJ","Hardin JR","Twal WO","Wilson DA"],"additional_accession":[]},"is_claimable":false,"name":"Race disparity in blood sphingolipidomics associated with lupus cardiovascular comorbidity.","description":"Systemic lupus erythematous (SLE) is a chronic multi-organ autoimmune disease. Genetic and environmental factors contribute to disease onset and severity. Sphingolipids are signaling molecules involved in regulating cell functions and have been associated with multiple genetic disease processes. African-Americans are more likely to suffer from SLE morbidity than Whites. The Medical University of South Carolina has banked plasma samples from a well-characterized lupus cohort that includes African-Americans and Whites. This study examined the influence of race on plasma sphingolipid profiles in SLE patients and association of sphingolipid levels with comorbid atherosclerosis and SLE disease activity. Mass spectrometry revealed that healthy African-Americans had higher sphingomyelin levels an","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-21T21:08:13.875Z","creation":"2020-05-21T20:52:33Z"},"accession":"S-EPMC6867606","cross_references":{"pubmed":["31747417"],"doi":["10.1371/journal.pone.0224496"]}}