{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Beurton F"],"funding":["Wellcome Trust Senior Research Fellowship","Proteomics French Infrastructure","Fondation ARC","Cancer Research UK","Agence Nationale de la Recherche","Labex GRAL","Wellcome Trust"],"pagination":["11164-11180"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6868398"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["47(21)"],"pubmed_abstract":["The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although H3K4me3 is widely associated with gene expression, the effects of CFP1 loss vary, suggesting additional chromatin factors contribute to context dependent effects. Using a proteomics approach, we identified CFP1 associated proteins and an unexpected direct link between Caenorhabditis elegans CFP-1 and an Rpd3/Sin3 small (SIN3S) histone deacetylase complex. Supporting a functional connection, we find that mutants of COMPASS and SIN3 complex components genetically interact and have similar phenotypic defects including misregulation of common genes. CFP-1 directly binds SIN-3 through a region including the conserved PAH1 dom"],"journal":["Nucleic acids research"],"pubmed_title":["Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans."],"pmcid":["PMC6868398"],"funding_grant_id":["15-CE12-0018-01","155265","ANR-10-LABX-49-01","101863/Z/13/Z","C6946/A14492","092096","101863"],"pubmed_authors":["Coute Y","Caron M","Spichty M","Dong Y","Huang N","Beurton F","Appert A","Cluet D","Stempor P","Bedet C","Polveche H","Herbette M","Ahringer J","Palladino F","Chen RA"],"additional_accession":[]},"is_claimable":false,"name":"Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans.","description":"The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although H3K4me3 is widely associated with gene expression, the effects of CFP1 loss vary, suggesting additional chromatin factors contribute to context dependent effects. Using a proteomics approach, we identified CFP1 associated proteins and an unexpected direct link between Caenorhabditis elegans CFP-1 and an Rpd3/Sin3 small (SIN3S) histone deacetylase complex. Supporting a functional connection, we find that mutants of COMPASS and SIN3 complex components genetically interact and have similar phenotypic defects including misregulation of common genes. CFP-1 directly binds SIN-3 through a region including the conserved PAH1 dom","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2026-04-07T19:17:58.437Z","creation":"2020-05-21T20:11:55Z"},"accession":"S-EPMC6868398","cross_references":{"pubmed":["31602465"],"doi":["10.1093/nar/gkz880"]}}