biostudies-literatureUnknown14(11)Chmiel C“Gottfried und Julia Bangerter-Rhyner-Stiftung”, fund of the Swiss Academy of Medical SciencesThermo Fisher ScientificIBDnet, Swiss Research and Communication Network on Inflammatory Bowel Disease<h4>Background</h4>Diagnosis of inflammatory bowel disease (IBD) in primary care (PC) is challenging and associated with a considerable diagnostic delay. Using a calprotectin test for any PC patient with abdominal complaints would cause significant costs. The 8-item-questionnaire CalproQuest was developed to increase the pre-test probability for a positive Calprotectin. It is a feasible instrument to assess IBD in PC, but has not yet been evaluated in clinical routine. This study, therefore, aimed to validate whether the CalproQuest increases pretest-probability for a positive fecal Calprotectin.<h4>Methods</h4>Prospective diagnostic trial. The CalproQuest consists of 4 major and 4 minor questions suggestive for IBD. It is considered positive if ≥ 2 major or 1 major and 2 minor criteria arPloS onee0224961https://www.ebi.ac.uk/biostudies/studies/S-EPMC6872045biostudies-literatureCan the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study.PMC6872045Sulz MCSenn OTandjung RScherz NChmiel CZahnd NVavricka SHasler SRosemann TRogler GfalseCan the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study.<h4>Background</h4>Diagnosis of inflammatory bowel disease (IBD) in primary care (PC) is challenging and associated with a considerable diagnostic delay. Using a calprotectin test for any PC patient with abdominal complaints would cause significant costs. The 8-item-questionnaire CalproQuest was developed to increase the pre-test probability for a positive Calprotectin. It is a feasible instrument to assess IBD in PC, but has not yet been evaluated in clinical routine. This study, therefore, aimed to validate whether the CalproQuest increases pretest-probability for a positive fecal Calprotectin.<h4>Methods</h4>Prospective diagnostic trial. The CalproQuest consists of 4 major and 4 minor questions suggestive for IBD. It is considered positive if ≥ 2 major or 1 major and 2 minor criteria ar2019-01-01T00:00:00Z20192025-04-04T13:27:57.091Z2020-05-21T21:18:05ZS-EPMC68720453175136010.1371/journal.pone.0224961