biostudies-literatureXiong CResearch and DevelopmentNIBIB NIH HHSNIA NIH HHSAlzheimer&apos;s AssociationScience and Industry Endowment FundNational Institute on AgingDeutsches Zentrum für Neurodegenerative ErkrankungenDementia Collaborative Research Centres, AustraliaAlzheimer&apos;s Drug Discovery FoundationJapan Agency for Medical Research and DevelopmentKorea Health Industry Development InstituteNational Health and Medical Research CouncilNINDS NIH HHSMcCusker Alzheimer&apos;s Research Foundation1448-1457https://www.ebi.ac.uk/biostudies/studies/S-EPMC6874758biostudies-literatureUnknown15(11)<h4>Introduction</h4>Large longitudinal biomarkers database focusing on middle age is needed for Alzheimer's disease (AD) prevention.<h4>Methods</h4>Data for cerebrospinal fluid analytes, molecular imaging of cerebral fibrillar β-amyloid with positron emission tomography, magnetic resonance imaging-based brain structures, and clinical/cognitive outcomes were harmonized across eight AD biomarker studies. Statistical power was estimated.<h4>Results</h4>The harmonized database included 7779 participants with clinical/cognitive data: 3542 were 18∼65 years at the baseline, 5865 had longitudinal cognitive data for a median of 4.7 years, 2473 participated in the cerebrospinal fluid studies (906 had longitudinal data), 2496 participated in the magnetic resonance imaging studies (1283 had longitudiAlzheimer's & dementia : the journal of the Alzheimer's AssociationA harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials.PMC6874758R01 AG059869R01 AG053550UF1AG032438R01 AG027161UF1 AG032438P50 AG033514P50 AG005681P01AG026276U19 AG032438P30 AG066507P01 AG0399131P30 AG062715P50AG033514U19 AG033655RF1 AG059869P30 NS098577RF1 AG053550RF1 AG027161R01 EB009352P01 AG026276R01 AG021155R01‐AG027161P01 AG003991U19‐AGO33655Koscik RLAgboola FHassenstab JDominantly Inherited Alzheimer NetworkFagan AMVillemagne VLBateman RJMasters CLSoldan AMorris JCMassoumzadeh PAlbert MBenzinger TLi YJohnson SCMcDade EMLuo JLi QXXiong CfalseA harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials.<h4>Introduction</h4>Large longitudinal biomarkers database focusing on middle age is needed for Alzheimer's disease (AD) prevention.<h4>Methods</h4>Data for cerebrospinal fluid analytes, molecular imaging of cerebral fibrillar β-amyloid with positron emission tomography, magnetic resonance imaging-based brain structures, and clinical/cognitive outcomes were harmonized across eight AD biomarker studies. Statistical power was estimated.<h4>Results</h4>The harmonized database included 7779 participants with clinical/cognitive data: 3542 were 18∼65 years at the baseline, 5865 had longitudinal cognitive data for a median of 4.7 years, 2473 participated in the cerebrospinal fluid studies (906 had longitudinal data), 2496 participated in the magnetic resonance imaging studies (1283 had longitudi2019-01-01T00:00:00Z2019 Nov2026-04-30T06:27:28.712Z2020-11-03T08:03:18ZS-EPMC68747583150624710.1016/j.jalz.2019.06.4955