{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(62)"],"submitter":["Kosec A"],"pubmed_abstract":["<h4>Background</h4>Breslow tumor thickness and mitotic rate are standardly used for risk stratification of patients with malignant melanoma. However, their prognostic value is relatively limited and a need for improved prognostication has been advocated. We aimed to screen the tumor tissue proteome in a search for potentially useful prognostic factors in early-stage cutaneous head and neck melanoma.<h4>Methodology and findings</h4>Proteomic profiles of archival formalin-fixed tissue samples of 31 patients (age 23-90 years) with early-stage head and neck cutaneous malignant melanoma (American Joint Committee on Cancer, AJCC, stage I/II) were determined and expression intensities were compared to those of melanocytic nevi, yielding ratios used in data analysis. Medical charts were retrospect"],"journal":["Oncotarget"],"pagination":["6713-6722"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6877100"],"repository":["biostudies-literature"],"pubmed_title":["Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: A proteomics-based study."],"pmcid":["PMC6877100"],"pubmed_authors":["Konjevoda P","Grgurevic L","Bedekovic V","Novak R","Trkulja V","Kosec A"],"additional_accession":[]},"is_claimable":false,"name":"Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: A proteomics-based study.","description":"<h4>Background</h4>Breslow tumor thickness and mitotic rate are standardly used for risk stratification of patients with malignant melanoma. However, their prognostic value is relatively limited and a need for improved prognostication has been advocated. We aimed to screen the tumor tissue proteome in a search for potentially useful prognostic factors in early-stage cutaneous head and neck melanoma.<h4>Methodology and findings</h4>Proteomic profiles of archival formalin-fixed tissue samples of 31 patients (age 23-90 years) with early-stage head and neck cutaneous malignant melanoma (American Joint Committee on Cancer, AJCC, stage I/II) were determined and expression intensities were compared to those of melanocytic nevi, yielding ratios used in data analysis. Medical charts were retrospect","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2026-05-04T06:24:17.697Z","creation":"2020-05-21T21:26:53Z"},"accession":"S-EPMC6877100","cross_references":{"pubmed":["31803364"],"doi":["10.18632/oncotarget.27333"]}}