{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Katsuyama T"],"funding":["NIAID NIH HHS","NIAMS NIH HHS","NIH","SICPA"],"pagination":["5411-5423"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6877308"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["129(12)"],"pubmed_abstract":["Systemic lupus erythematosus (SLE) is a devastating autoimmune disease in which hyperactive T cells play a critical role. Understanding molecular mechanisms underlying the T cell hyperactivity will lead to identification of specific therapeutic targets. Serine/arginine-rich splicing factor 1 (SRSF1) is an essential RNA-binding protein that controls posttranscriptional gene expression. We have demonstrated that SRSF1 levels are aberrantly decreased in T cells from patients with SLE and that they correlate with severe disease, yet the role of SRSF1 in T cell physiology and autoimmune disease is largely unknown. Here we show that T cell-restricted Srsf1-deficient mice develop systemic autoimmunity and lupus-nephritis. Mice exhibit increased frequencies of activated/effector T cells producing "],"journal":["The Journal of clinical investigation"],"pubmed_title":["Splicing factor SRSF1 controls T cell hyperactivity and systemic autoimmunity."],"pmcid":["PMC6877308"],"funding_grant_id":["R01AI42269","K01 AR060781","xxxx","R01 AI042269","R01 AR068974"],"pubmed_authors":["Li H","Comte D","Katsuyama T","Tsokos GC","Moulton VR"],"additional_accession":[]},"is_claimable":false,"name":"Splicing factor SRSF1 controls T cell hyperactivity and systemic autoimmunity.","description":"Systemic lupus erythematosus (SLE) is a devastating autoimmune disease in which hyperactive T cells play a critical role. Understanding molecular mechanisms underlying the T cell hyperactivity will lead to identification of specific therapeutic targets. Serine/arginine-rich splicing factor 1 (SRSF1) is an essential RNA-binding protein that controls posttranscriptional gene expression. We have demonstrated that SRSF1 levels are aberrantly decreased in T cells from patients with SLE and that they correlate with severe disease, yet the role of SRSF1 in T cell physiology and autoimmune disease is largely unknown. Here we show that T cell-restricted Srsf1-deficient mice develop systemic autoimmunity and lupus-nephritis. Mice exhibit increased frequencies of activated/effector T cells producing ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-04-26T01:28:29.461Z","creation":"2025-04-06T10:02:59.494Z"},"accession":"S-EPMC6877308","cross_references":{"pubmed":["31487268"],"doi":["10.1172/jci127949","10.1172/JCI127949"]}}